国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (3): 187-189.

• 论著 • 上一篇    下一篇

多种营养素干预与胎儿生长受限的关联研究

王亚菲, 裴丽君, 宋新明, 陈 功, 郑晓瑛   

  1. 100780 北京大学人口研究所
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 郑晓瑛

The Association Study Between Multi-nutrient Intervention and Fetal Intrauterine Growth Retardation

WANG Ya-fei， PEI Li-jun， SONG Xin-ming， CHEN Gong， ZHENG Xiao-ying   

  1. Institute of Population Research， Peking University， Beijing 100871， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-05-15 Online:2011-05-15
  • Contact: ZHENG Xiao-ying

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摘要： 目的：探讨胎儿生长受限（FGR）的危险因素，评价多种营养素干预对FGR的预防作用。方法：研究数据来源于全国4省18县进行的营养素社区干预性研究，对纳入研究妇女进行问卷调查并追踪随访其妊娠结局。FGR定义为妊娠满37周、出生体质量低于同妊娠时间平均出生体质量的2个标准差者。结果：共记录妊娠结局52 043例，其中单胎、活产、无畸形的新生儿50 769例。本研究单胎、活产、无畸形新生儿有FGR者共计628例，占1.24%。多因素Logistic回归分析显示，与FGR发生有关的因素包括母亲年龄、妊娠周数、胎儿性别、经济状况、被动吸烟、饮茶习惯和妊娠期贫血等。多种营养素干预减少了FGR的发生。结论：母亲年龄、妊娠周数、胎儿性别、经济状况、不良生活习惯、妊娠期疾病等是发生FGR的危险因素，而多种营养素干预可预防FGR的发生。

关键词: 胎儿生长迟缓, 危险因素, Logistic模型, 营养疗法, 干预性研究

Abstract: Objective： To evaluate the risk factors of intrauterine growth retardation，and to evaluate the prevention effect of multi-nutrient intervention against intrauterine growth retardation. Methods: The data was from multi?-nutrient intervention community study，which was carried out in 18 counties of 4 provinces nationwide. Then women included in the study was investigated，and followed up to record the pregnancy outcome. Results: 52 043 cases of pregnancy outcome were recorded， in which 50 769 cases were single， live births， and without malformation. According to the traditional definition， there were 134 cases of intrauterine growth retardation. The incidence rate was 0.26%. Multivariate logistic regression analysis shows that， the intrauterine growth retardation associated factors are maternal age， gestational age， fetal gender， economic status， passive smoking， drinking tea， anemia during pregnancy. Multi?-nutrient intervention reduced the incidence of intrauterine growth retardation. Conclusions: maternal age， gestational age， fetal gender， economic status， some bad habits， some disease during pregnancy is risk factors of intrauterine growth retardation. Multi?-nutrient intervention can prevent intrauterine growth retardation.

Key words: Fetal growth retardation, Risk factors, Logistic models, Nutrition therapy, Intervention studies