国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (1): 5-7.

• 论著 • 上一篇    下一篇

妊娠梅毒患者围生结局和临床治疗分析

谭洁，凌静，崔毓桂，刘嘉茵   

  1. 214400 江苏省江阴市，东南大学附属江阴市人民医院妇产科（谭洁，凌静）；南京医科大学第一附属医院生殖医学科（崔毓桂，刘嘉茵）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-01-15 发布日期:2014-01-15

Perinatal Outcomes of Pregnant Syphilis: a Clinical Analysis

TAN Jie，LING Jing，CUI Yu-gui，LIU Jia-yin   

  1. Department of Obstetrics and Gynecology，Jiangyin Hospital Affiliated to Southeast University，Jiangyin 214400，Jiangsu Province，China（TAN Jie，LING Jing）；Center of Reproductive Medicine，First Affiliated Hospital，Nanjing Medical University，Nanjing 210029，China（CUI Yu-gui，LIU Jia-yin）
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-01-15 Online:2014-01-15

PDF (PC)

7545

摘要： 目的：探讨妊娠合并梅毒对围生结局的影响，分析临床治疗对改善其妊娠结局及围生儿预后的临床意义。方法：2009年12月—2012年12月在江阴市人民医院妇产科就诊的妊娠梅毒患者79例，根据在妊娠期梅毒治疗情况分为全程治疗组（32例）、非全程治疗组（30例）和未治疗组（17例），比较3组妊娠结局、围生儿预后及新生儿先天梅毒的发生情况。结果：3组足月分娩率差异有统计学意义（P＜0.05），全程治疗组为93.8%，高于非全程治疗组（80.0%）及未治疗组（58.8%），但与非全程治疗组差异无统计学意义，与未治疗组差异有统计学意义（P＜0.05）；全程治疗组、非全程治疗组和未治疗组先天性梅毒儿发生例数分别为6，9，17例，发生率差异有统计学意义（P＜0.05）。3组早产发生例数分别为2，4，4例，发生率差异无统计学意义（P＞0.05）。3组死胎的发生例数分别为0，1，1例，发生率差异无统计学意义（P＞0.05）。结论：应建议妊娠期开展梅毒血清学的筛查工作，尤其某些特殊人群，早期发现妊娠期梅毒并进行全程的抗梅毒治疗，可显著改善其围生结局，降低先天梅毒儿发生率。

关键词: 妊娠, 梅毒, 妊娠结局, 治疗

Abstract: Objective: To analyze the influence of pregnancy combined with syphilis on perinatal outcomes，and to explore the clinical significance of standard treatment to improve the perinatal outcomes and the perinatal infant prognosis. Methods：This clinical analysis was based on 79 cases of pregnant syphilis diagnosed in our Department among Dec. 2009 and Dec. 2012. According to the treatment condition of pregnancy syphilis，79 cases were divided into three groups：the full course treatment group （Group A，32 cases），the none-full course treatment group （Group B，30 cases） and the none treatment group （Group C，17 cases）. The pregnancy outcomes，perinatal infant prognosis，and the case of congenital syphilis，were compared among three groups. Results：There was statistical significance in the term birth rate among three groups （P＜0.05）. The term birth rate in Group A was 93.8%，which was higher than those in Group B （80.0%，but P＞0.05） and Group C （58.8%，P＜0.05）. The cases of congenital syphilis in three groups were 6，9 and 17，respectively，with the statistical significance in the occurrence rate （P＜0.05）. The cases of pre-term birth in three groups were 2，4 and 4，respectively，without statistical significance in the occurrence rate （P＞0.05）. The cases of still birth in three groups were 0，1 and 1，respectively，without statistical significance in the occurrence rate（P＞0.05）. Conclusions：It is suggested that syphilis should be screened during pregnancy by the serological test. Early detection and standard treatment of syphilis are of two keys to improve the perinatal outcomes and to reduce the rate of congenital syphilis.

Key words: Pregnancy, Syphilis, Pregnancy outcome, Therapy