国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2014, Vol. 33 ›› Issue (1): 14-17.

• 论著 • 上一篇    下一篇

口服避孕药治疗卵巢子宫内膜异位症保守手术后疗效的Meta分析

涂佳慧，洛若愚，王淑君   

  1. 430060 武汉大学人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-01-15 发布日期:2014-01-15
  • 通讯作者: 洛若愚

Oral Contraceptive Treatment for Endometriosis Following Conservative Surgery：a Meta-analysis

TU Jia-hui，LUO Ruo-yu，WANG Shu-jun   

  1. Department of Obstetrics and Gynecology，Renmin Hospital of Wuhan University，Wuhan 430060，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-01-15 Online:2014-01-15
  • Contact: LUO Ruo-yu

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摘要： 目的：评价口服避孕药用于治疗卵巢子宫内膜异位症（EMs）手术后的临床效果。方法：检索Cochrane Library、PubMed、EMbase、CNKI、VIP、万方等数据库和手工检索2000—2013年间专业相关期刊。纳入EMs手术后使用口服避孕药治疗随机对照试验（RCT），按照Cochrane Handbook 5.0.1评价标准严格评价纳入研究的方法学质量，并使用RevMan 5.0软件进行Meta分析。结果：共纳入9个研究，3篇外文文献，6篇中文文献，共869例患者。Meta分析结果示：①口服避孕药组的EMs术后症状缓解率较对照组提高（OR=3.13，95%CI：1.66~6.00，P=0.000 5）；②口服避孕药组的EMs术后复发率明显降低（OR=0.25，95%CI：0.17~0.36，P＜0.000 01）；③口服避孕药组术后妊娠率与对照组差异无统计学意义（OR=1.55，95%CI：0.79~3.04，P=0.21）。结论：EMs术后使用口服避孕药可提高症状缓解率，能明显降低复发率，但不能提高术后妊娠率。但此结论尚需要大样本、多中心的研究进行验证。

关键词: 子宫内膜异位症, 手术后期间, 避孕药, 口服, Meta分析

Abstract: Objective: To evaluate the clinical effects of oral contraceptive for the treatment of endometriosis （EMs） after conservative surgery. Methods：We searched Pubmed，the Cochrane library，CBM，CNKI and Wan-Fang databases for the randomized controlled trials （RCTs） about oral contraceptive for the treatment of EMs after conservative surgery between 2000 and 2013. According to the evaluation standards of Cochrane Handbook 5.0.1，the RevMan 5.0 software for Meta analysis was used in this Meta-analysis. Results：9 studies involving 869 patients met the inclusion criteria，including 3 foreign articles and 6 Chinese articles. The results of Meta-analysis showed as follows：① The remission rate of oral contraceptive group increased（OR=3.13，95%CI：1.66-6.00，P=0.000 5）；② The oral contraceptive group of EMs′s postoperative recurrence rate obviously decreased （OR=0.25，95%CI：0.17-0.36，P＜0.000 01）；③ The pregnancy rate of the oral contraceptive group and comparative groups existed insignificant difference（OR=1.55，95%CI：0.79-3.04，P=0.21）. Conclusions：The oral contraceptive can improve the remission rate and reduce the recurrence rate. This Meta-analysis results still need to be verified by large samples and multicenter studies.

Key words: Endometriosis, Postoperative period, Contraceptives, oral, Meta-analysis