国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (4): 302-305.

• 综述 • 上一篇    下一篇

弹性纤维及其相关基因与盆腔脏器脱垂

张晶,黄向华

  

  1. 050000 石家庄，河北医科大学第二医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 黄向华

The Relationship Between Elastic Fibers, Expression of Fibulin-5 and Lysyl Oxidase-like 1 and Pelvic Organ Prolapse

ZHANG Jing, HUANG Xiang-hua   

  1. The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15
  • Contact: HUANG Xiang-hua

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摘要： 盆腔脏器脱垂（pelvic organ prolapse, POP）的发生与盆底组织结构及功能完整性被破坏
有关。胶原纤维和弹性纤维是盆底筋膜和韧带的主要成分，纤维成分代谢异常可能是POP的发病机制之
一。胶原纤维的合成减少或降解增加可能导致POP发生，盆底组织中含有极其丰富的弹性纤维，对生殖
道组织调整自身去适应妊娠时的巨大伸展变化及产后修复非常重要。有研究发现，盆底组织中功能性弹
性纤维数量减少及其平衡态紊乱可能是POP的病因学基础。

关键词: 脱垂, 弹性组织, 弹性蛋白, 细胞外基质蛋白质类

Abstract: Pelvic organ prolapse（POP）is strongly associated with damage in strutural and functional
integrity of pelvic floor tissues. Collagen fibers and elastic fibers are the major components of connective tissue.
Their metabolic abnormalities may be one of the pathogenesis of POP. Reduction of collagen fibers synthesis or
inerease of degradation may lead to POP. Pelvic floor tissues are extremely rich in elastic fibers. It is important
for reproductive tissues accommodate enormous expansion in pregnancy and involution after parturition. The
study has that failure of elastic fiber homeostasis may be the basis of the etiology of POP.

Key words: Prolapse, Elastic tissue, Elastin, Extracellular Matrix Proteins