国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2010, Vol. 29 ›› Issue (4): 298-301.

• 综述 • 上一篇    下一篇

模式识别受体基因多态性与输卵管沙眼衣原体感染

章君华,徐键   

  1. 310006 杭州，浙江大学医学院附属妇产科医院（章 君华：永康市妇幼保健院在职研究生）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 徐键

PPRs and Gene Polymorphisms and Chlamydia Trachomatis-associated Tubal Factor Infertility

ZHANG Jun-hua,XU Jian   

  1. Women’s Hospital，School of Medicine，Zhejiang Universtity，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-07-15 Online:2010-07-15
  • Contact: XU Jian

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摘要： 沙眼衣原体（CT）是最常见的性传播疾病的病原体之一。患者感染后常因无症状而未能
及时接受治疗。持续性CT感染可引起输卵管损害，导致输卵管性不孕等严重后果。清除病原体的关键在
于机体正常的免疫应答。Toll 样受体（TLR）家族和核苷酸结合的寡聚结构域（NOD）家族是固有免疫系统
的关键模式识别受体（PRRs），在CT感染识别和启动免疫应答中发挥重要作用。近年较多证据关注到CT
感染后输卵管性不孕的遗传学特征，并发现部分PPRs、人类白细胞抗原和细胞因子的基因多态性与CT
易感性和输卵管感染后结局相关。

关键词: 衣原体, 沙眼, Toll 样受体, 多态性, 限制性片段长度, 不育, 女(雌)性, 输卵管, NOD 蛋 白, 关键模式识别受体

Abstract: Chlamydia（C.）trachomatis is the most prevalent sexually transmitted diseases. Due to the
mostly asymptomatic course of infection，these women will most likely not be treated and have persistent C.
trachomatis infections，which may increase the risk of tubal pathology and tubal factor infertility. Therefore，an
adequate immune response is essential to clear the pathogen. Pattern recognition receptors（PRRs）of the toll-
like receptor（TLR）and nucleotide-binding oligomerization domain（NOD）families play a substantial role in
recognizing C. trachomatis and initiating the immune response. Recent studies have shown the value of genetic
trait in C. trachomatis-associated tubal factor infertility. Genetic variations in some PPRs and human leukocyte
antigen and cytokine genes tend to increase the susceptibility，course and outcome of C. trachomatis infections.

Key words: Chlamydia trachomatis, Toll-like receptors, Polymorphism, restriction fragment length, Infertility, female, Fallopian tubes, Nucleotide-binding oligomerization domain, Pattern recognition receptors