国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2015, Vol. 34 ›› Issue (5): 429-432.

• 综述 • 上一篇    下一篇

促性腺激素释放激素激动剂在辅助生殖技术黄体支持中的应用

欧阳冬香，伍琼芳   

  1. 330006 南昌大学医学院（欧阳冬香）；江西省妇幼保健院生殖医学中心（伍琼芳）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-09-15 发布日期:2015-09-15
  • 通讯作者: 伍琼芳

Administration of GnRH Agonist for the Luteal Phase Support in ART

OUYANG Dong-xiang，WU Qiong-fang   

  1. Medical College of Nanchang University，Nanchang 330006，China（OUYANG Dong-xiang）；Reproductive Medicine Center，Jiangxi Maternal and Child Health Hospital，Nanchang 330006，China（WU Qiong-fang）
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-09-15 Online:2015-09-15
  • Contact: WU Qiong-fang

PDF (PC)

7527

摘要： 在辅助生殖技术（assisted reproduction technique，ART）周期中，控制性超促排卵及取卵后容易导致黄体功能不全，为了解决这个问题，常规需要在ART周期中进行黄体支持（luteal phase support，LPS）。目前疗效肯定的LPS方案是单独或者联合使用不同剂量孕激素和人绒毛膜促性腺激素（human chorionic gonadotropin，hCG），但hCG会增加卵巢过度刺激综合征（ovarian hyperstimulation syndrome，OHSS）发生的风险。近年来有学者发现在LPS中添加促性腺激素释放激素激动剂（gonadotropin-releasing hormone agonist，GnRHa）不仅可减少OHSS的发生，还能获得良好的妊娠结局。虽然如此，目前有关GnRHa使用剂型、剂量、给药途径、时间、机制和效果仍不清楚，尚需进一步探索。

关键词: 促性腺素释放激素, 黄体保持, 生殖技术, 辅助, 受精, 体外, 胚胎移植, 促性腺激素释放激素激动剂

Abstract: The luteal phase defect frequently occurs after the controlled ovarian stimulation and follicular aspiration in assisted reproduction techniques (ARTs). As a clinical routine, luteal phase support (LPS) is recommended in ART cycles. The LPS treatment with definite curative effect is progesterone alone or progesterone plus hCG. However, hCG is associated with the increased risk of OHSS. Recently, it was showed that the added GnRH agonist in LPS treatment could decrease the OHSS risk, but also improve the outcomes of pregnancy. It is necessary to explore further the formulation of GnRH agonist, the minimal effective dose and the most effective timing and protocol, as well as its exact mechanism.

Key words: Gonadotropin-releasing hormone, Corpus luteum maintenance, Reproductive techniques, assisted, Fertilization in vitro, Embryo transfer, Gonadotropin-releasing hormone agonist