国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2011, Vol. 30 ›› Issue (5): 420-424.

• 综述 • 上一篇    

CXCL12，CCL2，RANTES及其受体与妊娠免疫耐受

张 钰,李 奕   

  1. 300211 天津医科大学附属第二医院计划生育科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-09-15 发布日期:2011-09-15

CXCL12， CCL2， RANTES and Their Receptors with Pregnancy Immune Tolerance

ZHANG Yu， LI Yi   

  1. Department of Family Planning， the Second Hospital of Tianjin Medical University， Tianjin 300211， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-09-15 Online:2011-09-15

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摘要： 妊娠免疫耐受是正常妊娠时母体形成的一种特殊类型的免疫耐受，其关键在于母胎界面局部的免疫耐受状态。趋化因子及其受体表达于母胎界面，参与滋养细胞的侵蚀和免疫细胞的活化和游走等过程，在诱导妊娠免疫耐受中发挥重要作用。基质细胞衍生因子1（CXCL12）、单核细胞趋化蛋白1（CCL2）和正常T细胞活化后所表达和分泌的调节蛋白（RANTES）属于趋化因子家族，综述3种趋化因子及其受体在妊娠免疫耐受中的作用。

关键词: 趋化因子CXCL12, 趋化因子CCL2, 趋化因子CCL5, 受体, 趋化因子, 免疫耐受

Abstract: Pregnancy immune tolerance is a special type of immunological tolerance formed by maternal immune system during pregnancy. The status of immunological tolerance within maternal?-fetal interface is very important for maintaining pregnancy. The chemokines and their receptors expressed in maternal?fetal interface play important roles in the induced immune tolerance， participating in the invasion of trophoblasts，activation and migration of immunocytes. Stromal cell-derived factor-1（CXCL12）， monocyte chemotactic protein-1（CCL2）， and the regulated upon activation normal T cell expressed and secreted（RANTES）， belong to the super family of chemokines. In this article， we reviewed the effects of those chemokines and their receptors in the pregnancy immune tolerance.

Key words: Chemokine CXCL12, Chemokine CCL2, Chemokine CCL5, Receptors, chemokine, Immune tolerance