雄性生殖系统中瘦素表达及功能的研究进展

doi:10.12280/gjszjk.20200499

摘要/Abstract

摘要：

男性生育力呈下降趋势,阐明其发生机制有助于男性不育症的精准医疗。瘦素是一种主要由脂肪组织产生的激素,在调节机体能量代谢、参与炎性反应、促进生殖系统发育及维持其正常功能等方面具有重要的作用。瘦素及其受体在哺乳动物下丘脑-垂体-性腺（HPG）轴的内分泌器官、睾丸、生殖道、附属生殖腺以及精子中均有广泛表达,其表达异常与雄性生殖系统发育迟缓或功能障碍相关。阐明瘦素在雄性生殖系统中的表达及作用机制可为临床上治疗男性不育等相关疾病提供重要的理论基础。

关键词: 瘦素, 受体, 瘦素, 泌尿生殖系统, 生育力, 精子发生, 下丘脑-垂体-性腺轴

Abstract:

The downward trend in male fertility has become increasingly obvious in the world. To clarify the etiology and pathogenesis of this trend is very helpful for the precision treatment of male infertility. Leptin, a hormone produced mainly by adipose tissue, plays an important role in regulating energy metabolism, responding to inflammation, promoting the development of reproductive system and maintaining reproductive function. Leptin and its receptor can widely express in mammals′ HPG axis, testicular tissue, genital tract, accessory glands and sperm. The abnormal expression of leptin is related to the delayed development or dysfunction of the male reproductive system. To verify the leptin expression in male reproductive system and to elucidate its molecular mechanism may provide critical theoretical evidences for the clinical treatment of reproductive diseases such as male infertility.

Key words: Leptin, Receptors, leptin, Urogenital system, Fertility, Spermatogenesis, Hypothalamus-pituitary-gonad axis

金明昊, 黄文一, 张梦旖, 张一苇, 刘悦, 丁之德. 雄性生殖系统中瘦素表达及功能的研究进展[J]. 国际生殖健康/计划生育, 2021, 40(1): 38-43.

JIN Ming-hao, HUANG Wen-yi, ZHANG Meng-yi, ZHANG Yi-wei, LIU Yue, DING Zhi-de. Leptin and Male Reproduction[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(1): 38-43.

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