免疫因素在反复种植失败中的研究进展

doi:10.12280/gjszjk.20200352

摘要/Abstract

摘要：

随着辅助生殖技术的发展妊娠率逐年提高,但仍有部分患者反复种植失败（RIF）,某种程度上RIF成为体外受精（IVF）或胞浆内单精子注射（ICSI）成功的限制因素。RIF的机制尚不明确,常见原因包括胚胎质量缺陷、子宫内膜容受性降低等。妊娠是“同种异体移植物”胚胎侵入子宫内膜的过程,随着生殖免疫学的发展,人们越来越多地关注到了免疫因素在RIF中的重要影响。妊娠早期子宫内膜内母胎界面发生的免疫事件极其复杂,涉及大量具有免疫调节特性的免疫细胞和分子,自身免疫抗体与IVF/ICSI的结局之间也存在密切关系。越来越多的研究表明,免疫因素可能是导致不明原因RIF的主要病因。综述RIF的免疫因素及常见的针对RIF的免疫调节治疗。

关键词: 胚胎移植, 胚胎植入, 免疫耐受, 自身抗体, 免疫疗法

Abstract:

With the development of assisted reproductive technology, the pregnancy rate has been increasing year by year, but some patients still suffer from recurrent implantation failure (RIF). To some extent RIF is a limiting factor of the success of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). The mechanism of RIF is still unclear, and common causes include the defects in embryo quality, the decreased endometrial receptivity and so on. Pregnancy is a process in which "allograft" embryos invade the endometrium. With the development of reproductive immunology, people pay more and more attention to the significant role of immune factors in RIF. The immune events in maternal-fetal interface during early pregnancy are extremely complex, involving a large number of immune cells and molecules. There is also a close relationship between the IVF/ICSI outcome and autoimmune antibody. A growing number of studies have shown that immunological factors may be the main cause of RIF with unknown causes. This article summarizes the immunological factors of RIF and the common immunotherapy for RIF.

Key words: Embryo transfer, Embryo implantation, Immune tolerance, Autoantibodies, Immunotherapy

周羽西, 谢奇君, 沈嵘, 凌秀凤, 赵纯. 免疫因素在反复种植失败中的研究进展[J]. 国际生殖健康/计划生育, 2021, 40(2): 147-152.

ZHOU Yu-xi, XIE Qi-jun, SHEN Rong, LING Xiu-feng, ZHAO Chun. Advances in Immune Factors of Recurrent Implantation Failure[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(2): 147-152.

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