国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (5): 413-417.

• 综述 • 上一篇    下一篇

女性肿瘤患者生育力保存的研究现状

张聪,张娜   

  1. 050011 石家庄,河北医科大学第四医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-25 发布日期:2016-10-25
  • 通讯作者: 张娜

Fertility Preservation of Women with Tumor

ZHANG Cong, ZHANG Na   

  1. Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-25 Online:2016-10-25
  • Contact: ZHANG Na

摘要: 近年来年轻的女性肿瘤患者逐年增加。抗肿瘤治疗虽然能提高患者的生存率,但大量放化疗严重损害女性生育能力,因此育龄期女性肿瘤患者有生育力保存的需要。目前,已有乳腺癌、血液系统肿瘤患者成功保存生育力的先例。依据患者所患肿瘤类型及具体情况的不同,可选择采用胚胎冷冻、卵母细胞冷冻和卵巢组织冷冻3种方式来保存女性生育力,并制定出个性化的生育力保存方案。3种冷冻方式各有优缺点。胚胎冷冻和卵母细胞冷冻方式虽技术成熟但需要在肿瘤治疗前等待一定的时间。卵巢组织冷冻后可快速进行抗肿瘤治疗,但技术尚不成熟。生育力保存方案成功与否受多种因素影响,包括患者的年龄、所患肿瘤的类型及治疗方案等。就近年女性肿瘤患者生育力保存的研究进行概述。

关键词: 女(雌)性, 肿瘤, 生育力, 低温保存, 卵母细胞, 卵巢

Abstract: More and more young women are diagnosed with cancer. Radiotherapies and chemotherapies increase the survival rate of cancer patients, while their reproductive ability could be damaged by those anti-tumor treatments. At present, there are some reports about the fertility preservation in patients suffering from breast cancer and haematological malignances. According to the tumor types and other situations, the embryo cryopreservation, oocyte cryopreservation and ovarian tissue cryopreservation can be recommended as a personalized program of fertility preservation. Three kinds of freezing methods have their advantages and disadvantages. The embryo freezing and egg freezing need to extend the waiting time before anti-tumor treatment, but these technologies are relatively mature. Compared with them, the ovarian tissue cryopreservation do not delay the anti-tumor treatment, but the technology is not yet mature. The success rate of fertility preservation program is also affected by many factors, such as the age of patient, the type of tumor, and the specific treatment. In this paper, we reviewed in the research progress of fertility preservation of tumor women.

Key words: Female, Neoplasms, Fertility, Cryopreservation, Oocytes, Ovary