国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (5): 409-412.

• 综述 • 上一篇    下一篇

女性生育力保存技术的研究进展

李微，张娜   

  1. 050011 石家庄，河北医科大学第四医院生殖医学科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-25 发布日期:2016-10-25
  • 通讯作者: 张娜

Research Progress of Female Fertility Preservation

LI Wei, ZHANG Na   

  1. Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University，Shijiazhuang 050011, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-25 Online:2016-10-25
  • Contact: ZHANG Na

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摘要： 近年女性生育力保存的问题引起人们的密切关注，其适用人群包括卵巢功能不全患者、肿瘤患者、自身免疫性疾病患者、欲将生育年龄延后的人群等。由于放化疗药物的使用造成女性生育力下降，严重影响了患者的生活质量，因此年轻的肿瘤患者可能成为生育力保存的主要目标人群。生育力保存的方式包括3种：胚胎冷冻、卵母细胞冷冻及卵巢组织冷冻。胚胎冷冻技术已经成功应用于临床，卵母细胞冷冻技术亦日趋成熟，但卵巢组织冷冻技术尚处于研究初始阶段，应用前景广泛。3种生育力保存方式均可采用慢速冷冻方法和玻璃化冷冻方法进行冷冻保存，2种方法各有优缺点。综述近年来对生育力保存的范围、方法及今后需要解决的问题，为进一步研究提供思路。

关键词: 女（雌）性, 生育力, 低温保存, 卵母细胞, 肿瘤

Abstract: The fertility preservation is suitable for those patients with primary ovarian insufficiency, tumor, autoimmune disease, and those people who want to postpone parenthood. Young women with tumor will be the main population of fertility preservation because radiotherapy and chemotherapy always impaire their fertility and living quality. There are three kinds of fertility preservation technology: embryo freezing, oocyte freezing and ovarian tissue cryopreservation. The technology of embryo freezing has been successfully used in clinical practice. The technology of oocyte freezing is getting mature. However, the technology of ovarian tissue cryopreservation is still at the early stage of research. Both of slow-freezing method and virtification method can be applied in fertility preservation techniques, with own advantages and disadvantages. The paper mainly introduces the methods of fertility preservation and the problems needed to be solved.

Key words: Female, Fertility, Cryopreservation, Oocytes, Neoplasms