国际生殖健康/计划生育杂志

国际生殖健康/计划生育 ›› 2016, Vol. 35 ›› Issue (6): 498-501.

• 综述 • 上一篇    下一篇

卵巢功能早衰致不孕症的治疗现状及进展

吴云青，宋丹，李红   

  1. 215002 南京医科大学附属苏州医院生殖与遗传中心
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-12-25 发布日期:2016-12-25
  • 通讯作者: 李红

Progress in Treatment of Infertility Related to Premature Ovarian Failure

WU Yun-qing, SONG Dan, LI Hong   

  1. Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215002, Jiangsu Province, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-12-25 Online:2016-12-25
  • Contact: LI Hong

PDF (PC)

8273

摘要： 卵巢功能早衰（POF）是指女性在40岁之前发生闭经，以高卵泡刺激素及低雌激素水平为特征，对年轻女性内分泌功能、生育能力及心理造成了严重影响。近年来，POF在女性不孕患者中的比例呈上升趋势。目前，POF所致闭经及低雌激素状态可通过激素替代治疗（HRT）得到改善，而POF所致不孕症的治疗仍处于探索阶段，包括促排卵、供卵、卵子冷冻技术、基因治疗、干细胞治疗以及体外激活（IVA）剩余的休眠卵泡等。近年来，基因及干细胞治疗在动物实验中取得了一定进展，为POF患者生育能力的恢复带来了希望；IVA是POF不孕治疗的新探索，可能让一些POF患者拥有携带自身基因的后代，尽管成功率较低，但已有成功的案例报道。对POF所致不孕症的治疗现状及研究进展进行综述。

关键词: 卵巢功能早衰, 不育, 女（雌）性, 基因疗法, 干细胞, 体外激活

Abstract: Premature ovarian failure（ＰＯＦ） is diagnosed by amenorrhea, along with the elevated follicle stimulating hormone（ＦＳＨ） and the decreased estrogen （Ｅ２） levels in women before 40 years old. POF has a severe impact on the endocrine function, fertility and mental state of those women. In recent years, the proportion of patients with POF in female infertility has a rising trend. The amenorrhea and low-estrogen level caused by POF can be improved by hormone replacement therapy （ＨＲＴ）, while the treatment for infertility need more exploratory study and clinical practice, including ovulation induction, oocyte donation transplant, egg cryopreservation technology, as well as some new technologies such as gene therapy, stem cells therapy and in-vitro activation（ＩＶＡ）. The gene therapy and the stem cells therapy have been made some progress in animal tests. These achievements bring POF patients a new hope in the recovery of fertility. IVA is a further exploration to activate the residual dormant follicles for those POF infertility women, although the success rate is not satisfactory. However, there have been some successful cases of IVA treatment. In this paper, the progress in the treatment of infertility related to POF was discussed.

Key words: Ovarian failure, premature, Infertility, female, Gene therapy, Stem cells, In-vitro activation