维生素D在多囊卵巢综合征患者辅助生殖中的应用进展

doi:10.12280/gjszjk.20250274

摘要/Abstract

摘要：

多囊卵巢综合征（polycystic ovary syndrome，PCOS）是育龄期女性常见的内分泌代谢紊乱性疾病，也是导致女性不孕的主要原因之一。近年研究发现，维生素D（vitamin D，VD）水平与PCOS患者的临床特征及发病机制相关，对其生殖功能和辅助生殖技术（assisted reproductive technology，ART）助孕结局具有潜在影响。VD改善ART助孕结局的可能机制是多方面的：VD可通过调节下丘脑-垂体-卵巢轴功能、改善胰岛素抵抗及高雄激素血症，从而优化卵泡发育与排卵；VD还能通过调控子宫内膜容受性关键基因、子宫脂肪因子等调节子宫内膜微环境，为胚胎着床创造有利条件。然而，目前关于VD对PCOS患者ART助孕结局的影响仍存在争议，对于VD补充的推荐剂量、给药途径及安全性尚不明确，未来仍需开展大规模、高质量的随机对照研究，以明确其对PCOS患者妊娠结局的影响，并确立标准化的补充策略。

关键词: 多囊卵巢综合征, 不育，女性, 维生素D, 生殖技术，辅助, 妊娠结局

Abstract:

Polycystic ovary syndrome (PCOS), a prevalent endocrine and metabolic disorder among women of reproductive age, is one of the primary causes of female infertility. Recent studies have demonstrated that the level of vitamin D (VD) was correlated with the clinical characteristics and pathogenesis of PCOS, influencing reproductive function and outcomes of assisted reproductive technology (ART). VD may improve ART outcomes through multiple mechanisms: by regulating the hypothalamic-pituitary-ovarian axis to improve insulin resistance and hyperandrogenemia, thereby optimizing follicular development and ovulation; and by modulating the endometrial microenvironment via key receptivity genes and uterine adipokines to support embryo implantation. However, its impact on ART outcomes of PCOS women remains controversial, with the indeterminacy in optimal dosage, route and safety. Future large-scale, high-quality randomized controlled trials are needed to clarify its effects on pregnancy outcomes and establish standardized supplementation strategies.

Key words: Polycystic ovary syndrome, Infertility, female, Vitamin D, Reproductive techniques, assisted, Pregnancy outcome

孔璟, 于岚, 张翠莲. 维生素D在多囊卵巢综合征患者辅助生殖中的应用进展[J]. 国际生殖健康/计划生育杂志, 2026, 45(2): 154-159.

KONG Jing, YU Lan, ZHANG Cui-lian. The Impact of Vitamin D on Assisted Reproductive Technology Outcomes in Women with Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2026, 45(2): 154-159.

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