Application of High-Throughput Transcriptome Sequencing in Evaluation of Endometrial Receptivity

doi:10.12280/gjszjk.20200190

Abstract

Abstract:

The good endometrial receptivity is a key factor for embryo implantation. The gene expression profile of endometrial tissue cells in the receptive period is closely related to the endometrial receptivity. High-throughput transcriptome sequencing technology can obtain gene expression profiles of the endometrium at different periods of menstruation, as well as microRNA (miRNA) and long non-coding RNA (lncRNA) sequences that regulate gene expression. Combined with bioinformatics analysis, these profiles are very helpful for us to understand the expression of specific genes in the endometrium during the receptivity period, and provide technical support for the mechanism study. This high-throughput method may be used for the diagnosis and treatment of patients with infertility and repeated implantation failure. This review summarized the research progress of high-throughput transcriptome sequencing in the evaluation of endometrial receptivity and embryo implantation.

Key words: High-throughput nucleotide sequencing, Implantation window, Genes, Endometrium, Epigenesis, genetic, Fertilization in vitro, Embryo transfer

BAI Ta-ji, HE Jin-ying, MA Yu-zhen. Application of High-Throughput Transcriptome Sequencing in Evaluation of Endometrial Receptivity[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(1): 49-52.

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