The Mechanism of Platelet-Rich Plasma Therapy in Thin Endometrium

doi:10.12280/gjszjk.20210162

Abstract

Abstract:

Thin endometrium can lead to the decreased rates of clinical pregnancy and live birth. At present, there is no optimal plan to improve endometrial thickness in patients with thin endometrium. As an auxiliary method for emerging endometrial preparation, platelet-rich plasma (PRP) perfusion therapy may have a complex mechanism in the treatment of thin endometrium. The platelet concentration in PRP is higher than that in whole blood. The basic principle and therapeutic potential of high concentration platelets are based on their ability to provide superphysiological quantities of essential growth factors for regenerative stimulation and to promote tissue repair with low healing potential. Based on the research progress of PRP, this paper focuses on the growth factors in PRP to promote cell proliferation, migration, and to regulate the proliferation and apoptosis of endometrial cells through NF-κB signaling pathway. The discussion will provide a reference for further study of the molecular basis and exact mechanism of PRP therapy.

Key words: Thin endometrium, Platelet-rich plasma, Growth factors, Intercellular signaling peptides and proteins, NF-kappa B

ZHENG Xiu-dan, YIN Lan-lan, WANG Yan-bo, MA Tian-zhong. The Mechanism of Platelet-Rich Plasma Therapy in Thin Endometrium[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(6): 490-494.

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