Relationship of Uterine Microbiota and Female Reproductive Healthy Diseases

doi:10.12280/gjszjk.20220111

Abstract

Abstract:

The microbiota colonizing in the uterine cavity has been demonstrated by next-generation sequencing and microbiome technology in recent years. The changes of uterine microbiota are connected not only with physiological factors, but also with female reproductive healthy diseases. However, the core composition of uterine microbiota and the relationship between the host and the microbiota still remain unknown. The disorder of uterine microbiota could be related to the pathogenesis and pathophysiology of chronic endometritis, recurrent implantation failure, endometriosis and intrauterine adhesion, etc. However, there is not a consensus on the unified protocol to assess the dysbiosis of uterine microbiota and the optimal treatment protocol to adjust above dysbiosis. To some extent, probiotics or prebiotics using in vagina can assist to treat the dysbiosis of uterine microbiota and to improve the pregnancy outcome. In this review, we discussed the uterine microbiota and its relationship with female reproductive health.

Key words: Uterine, Microbiota, Endometritis, Endometriosis, Tissue adhesion, Pregnancy outcome, Embryo implantation, Therapy

ZHANG Ming-wei, QI Qian-rong, XIE Qing-zhen. Relationship of Uterine Microbiota and Female Reproductive Healthy Diseases[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(3): 214-218.

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