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Table of Content

    15 May 2022, Volume 41 Issue 3
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    Original Article
    Case Report
    Review
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    Original Article
    A Preliminary Study on the Characteristics of Reproductive Tract Flora in Patients with Recurrent Spontaneous Abortion
    LIN Kai-li, GUO Jie, REN Shu-qing, SONG Dian-rong, ZHANG Ji-wen, ZHAO Lin, LU Di, WANG Run-jing
    2022, 41 (3):  177-183.  doi: 10.12280/gjszjk.20220153
    Abstract ( 2516 )   HTML ( 662 )   PDF (5329KB) ( 5778 )  

    Objective: To test the reproductive tract flora in patients with recurrent spontaneous abortion (RSA) and normal early pregnan women. Methods: From March 2021 to September 2021, 37 RSA patients who planned uterine cleaning in our hospital were selected as the RSA group, and 25 normal early pregnant women who planned artificial abortion as the normal early pregnant group. Bacterial 16S rRNAs in the vaginal secretions and uterine decidua tissues were tested by high-throughput sequencing. The characteristics of vaginal and uterine flora were compared between the two groups. Results: The diversity of vaginal flora was significantly increased, and the structural similarity of the flora among individuals was low in the RSA group when compared with the normal early pregnant group (both P<0.05). However, the dominant bacteria remained in Lactobacillus, and the abundance of Lactobacillus was significantly decreased in the RSA group (both P<0.05). The abundances of Gardnerella, Prevotella, Megasphaera, Dialister and Anaerococcus in the vagina of RSA group was significantly higher than those of the normal early pregnant group (all P>0.05). There were no significant changes in the diversity of uterine flora and the structural similarity of uterine flora among the individuals of the RSA group (P>0.05). However, the dominant bacteria was changed. The dominant bacteria was Lactobacillus_crispatus in the normal early pregnant group, while it was Lactobacillus_iners in the RSA group. The abundance of Bifidobacterium_bifidum and uncultured_Acinetobacter_sp decreased significantly in the uterine flora of RSA group (P<0.05), while the abundance of Bacteroides, Escherichia_Shigella and Ruminococcus_torques_group increased significantly (P<0.05). Conclusions: The vaginal and uterine microflora can be tested. The bacterial diversity of uterus was higher than that of vagina, but the abundance of dominant bacteria in the uterus was lower. The upward colonization of vaginal bacteria may be related to the formation of uterine flora. The specific bacterial flora in uterus, especially the change of dominant bacteria and the emergence of pathogenic bacteria, may be related to the occurrence of RSA.

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    Characteristics of Vaginal Flora in Patients with Recurrent Spontaneous Abortion
    CHENG Yang, ZHAO Min
    2022, 41 (3):  184-188.  doi: 10.12280/gjszjk.20220143
    Abstract ( 2524 )   HTML ( 323 )   PDF (7328KB) ( 5658 )  

    Objective: To analyze the characteristics of vaginal flora in patients with recurrent spontaneous abortion (RSA). Methods: The vaginal secretions of 20 patients with unexplained RSA (RSA group) and 20 women with normal early pregnancy abortion (control group) from December 2020 to September 2021 were collected. The vaginal flora of vaginal secretions were analyzed by 16S rRNA high-throughput sequencing technology. Results: The α diversity analysis showed that there were no significant differences in the Chao1 index, Shannon index, and Observed_OTU index between the two groups (all P>0.05). The β diversity analysis showed the significant difference in the vaginal bacterial community structure between the two groups (P<0.05). Taxonomic analysis showed that the common dominant bacteria at the gate, family and genus levels were Pseudomonas (Proteobacteria) in the two groups, and that the abundance of Pseudomonas in the RSA group at the gate, family and genus levels was 22.8%, 21.9%, and 21.9%, while the abundance of Pseudomonas in the control group was 17.9%, 17.3% and 17.3%, respectively. The abundance of Pseudomonas in the RSA group was increased significantly than that in the control group. Conclusions: Patients with RSA have vaginal flora imbalance, and the specific bacteria (such as Pseudomonas) may be related with the occurrence and development of RSA.

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    Immediate Versus Delayed Frozen-Thawed Embryo Transfer in Patients Following a Freeze-All IVF-ET Cycle
    JI Hui, DONG Li, ZHAO Chun, LING Xiu-feng, DING Hui
    2022, 41 (3):  189-194.  doi: 10.12280/gjszjk.20220063
    Abstract ( 2677 )   HTML ( 294 )   PDF (879KB) ( 5737 )  

    Objective: To investigate the pregnancy outcome after immediate versus delayed frozen-thawed embryo transfer (FET) following a freeze-all in vitro fertilization and embryo transfer (IVF-ET) cycle. Methods: This was a retrospective clinical study conducting FET treatment between June 2019 and March 2021. Infertile women were assigned to either the immediate FET group in which FET was performed in the first menstrual cycle following the failed IVF cycle (n=216), or the delayed FET group in which FET was performed in the second menstrual cycle following the failed IVF cycle (n=1 315). The propensity scoring matching (PSM) was used to control the confounding variables. The numbers of participants in the immediate and delayed FET groups after PSM were 206 and 377, respectively. This article compared the baseline characteristic and clinical outcomes within the two groups. Results: Basic parameters were not statistically different between the two groups (P>0.05). Patients in the immediate FET group had a comparable implantation rate, clinical pregnancy rate, ongoing pregnancy rate, and live birth rate than those in the delayed FET group (P>0.05). However, a significantly higher early miscarriage rate was depicted in the immediate FET group (22.0% vs. 11.5%, P=0.009). The significance still existed after adjusting for potential confounders in the multiple logistic regression analysis(aOR=2.094, 95%CI: 1.138~3.852, P=0.018). Conclusions: Although the early miscarriage rate was significantly higher following the immediate FET, it produced a similar pregnancy rate than the delayed FET while reducing time to pregnancy and emotional stress.

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    Intrapartum Factors Influencing Vaginal Birth after Cesarean
    LIU Guang-pu, ZHAO Ling, WANG Sheng-pu, REN Wei-na, ZHANG Hui-xin
    2022, 41 (3):  195-198.  doi: 10.12280/gjszjk.20220001
    Abstract ( 2302 )   HTML ( 312 )   PDF (763KB) ( 5633 )  

    Objective: To investigate the postpartum factors of vaginal birth after cesarean(VBAC). Methods: From January 2016 to November 2021, the pregnant women who underwent the trial of labor after cesarean section (TOLAC) in The Fourth Affiliated Hospital of Hebei Medical University were retrospectively analyzed. All included cases were the first vaginal delivery after a single cesarean section. The medical records included: maternal age, fetal head position during labor, latent period, whether use oxytocin to strengthen contractions during labor, fetal head position during active period (4-5 cm), and fetal position. The influencing factors of VBAC were analyzed by the univariate and multivariate logistic regression. Results: ①There were 319 pregnant women tried vaginal delivery, of which 236 had a final vaginal delivery, with a VBAC rate of 74.0%. ②The univariate analysis showed that the fetal head in the active phase (4-5 cm) was located at the level of the ischial spine or below (85.3% vs. 59.9%, OR=3.895, 95%CI: 2.282-6.647), and the fetal position is anterior occipital (83.6% vs. 62.8%, OR=3.020, 95%CI: 1.787-5.104) had higher successful rate of TOLAC. The success rate of TOLAC was lower in women who needed oxytocin strengthens contractions during labor (61.2% vs. 77.4%, OR=0.461, 95%CI: 0.260-0.818). There were no significant differences in the maternal age, fetal head position at delivery and latent period between the two groups (P>0.05). ③Multivariate analysis showed that oxytocin use during labor (OR=0.502, 95%CI: 0.267-0.943), fetal head at or below the level of ischial spine during active phase (OR=3.467, 95%CI: 1.990-6.042), fetal position at the anterior occipital (OR=2.633, 95%CI: 1.515-4.575) were independent influencing factors of VBAC. Conclusions: For pregnant women who underwent TOLAC, the maternal and fetal situation and labor progress should be closely monitored when the labor progresses to the beginning of active phase, the fetal head is still above the level of ischial spine, and fetal position is occipital/posterior, or oxytocin is used to strengthen the contractions during labor. If necessary, the surgical indications for cesarean section should be relaxed to ensure the safety of maternal and fetal.

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    Case Report
    Mitochondrial Disease Caused by GFM1 Gene Mutation:A Case Report and Literature Review
    DAI Xiao-juan, ZHENG Li-ling, CHEN Rou, YANG Xiao-yun
    2022, 41 (3):  199-203.  doi: 10.12280/gjszjk.20210554
    Abstract ( 2805 )   HTML ( 289 )   PDF (1288KB) ( 5887 )  

    Mitochondrial disease (MD) is a group of multi-systemic lesions caused by the mutations of mitochondrial genes or nuclear genes, which causes the dysfunction of mitochondrial metabolic enzyme, the disorder of ATP synthesis and the deficiency of energy production. The clinical manifestations are diverse and complex, and the prognoses are poor. There is no specific treatment at present. We reported a case of mitochondrial disease caused by GFM1 gene mutation. She was a female child of 1 year, presenting with repeated metabolic acidosis, hyperlactemia, growth and development lag. A homozygous mutation of GFM1 gene, C.688G>A was found. The amino acid was changed to p.Gly230ser (glycine>serine). Combined with literature review, this case of mitochondrial disease was analyzed so as to improve the clinical physicians′ understanding, and to provide some guidance for prenatal diagnosis.

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    A Case of Congenital Bilateral Absence of Vas Deferens with Spermatogenesis Failure
    FU Xu, ZHOU Ying, GU Yi-dong, WANG Jia-xiong, YANG Shen-min
    2022, 41 (3):  204-206.  doi: 10.12280/gjszjk.20220012
    Abstract ( 2935 )   HTML ( 226 )   PDF (2830KB) ( 5675 )  

    The congenital bilateral absence of vas deferens (CBAVD) is a common cause of obstructive azoospermia, in which spermatogenesis is mostly normal. In addition to the common mutations of cystic fibrotic transmembrane conductance regulator (CFTR), the mutations and copy number variation of adhesion G protein-coupled receptor G2 (ADGRG2) are also considered to be the pathogenesis of CBAVD. We report a case of CBAVD with spermatogenesis failure. Besides the bilateral absence of vas deferens, testicular histopathology indicated sertoli cell only syndrome. Genetic analysis was then performed to determine the causes. However, whole exome sequencing did not show the pathogenic variation and/or copy number variation of CBAVD as well as other genes related to spermatogenesis failure. The exact cause of this case was still unclear. The coexistence of CBAVD and spermatogenesis failure indicated the complexity of genetic etiology of azoospermia.

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    A Case of Confined Placental Mosaicism of Trisomy 16 Combined with Fetal Growth Restriction
    LI Shan-shan, SHEN Yong-mei, WEI Zhuo, CHEN Ling, YAO Li-ying, ZHANG Lei, LI Wen, CAO Jia-song, CHANG Ying
    2022, 41 (3):  207-209.  doi: 10.12280/gjszjk.20220014
    Abstract ( 3043 )   HTML ( 268 )   PDF (3467KB) ( 5722 )  

    We report a case of pregnant woman with fetal growth restriction (FGR). In this case, non-invasive prenatal testing showed the excessive chromosome 16, and the amniotic fluid genome copy number variants sequencing showed 16 trisomy mosaicism (16%). The pregnant woman came to our hospital at 37+2 weeks of gestation because the fetus was less than 3 weeks of gestational weeks. Emergency cesarean section was operated due to fetal distress. The newborn was a full-term low birth weight infant. The karyotype analysis and high-throughput sequencing of neonatal peripheral blood and placenta samples at multiple sites showed that the neonatal karyotype was 46, XX, 16qh+, and that the placenta tests were trisomy 16 mosaicism. Follow-up to five months after birth, the child was currently growing and developing normally. This case and literature suggest that it is necessary to combine FISH or SNP array when only CNV-Seq test showed chromosomal mosaicism by amniocentesis, to monitor ultrasound closely and give reasonable genetic counseling. The confined placental mosaicism of trisomy 16 can cause placental dysfunction and FGR.

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    Experience in Diagnosis and Treatment of Asymptomatic Submucous Uterine Cystic Adenomyosis
    WANG Bi-hui, LI Xue-jian, JIA A-ran, LI Yao-qi, WANG Hui-fei, GUO Yu-jing, JIA Zan-hui
    2022, 41 (3):  210-213.  doi: 10.12280/gjszjk.20210590
    Abstract ( 2350 )   HTML ( 250 )   PDF (8834KB) ( 5683 )  

    Cystic adenomyosis is a rare type of adenomyosis. We report a case of asymptomatic cystic adenomyosis in submucosa diagnosed and treated by hysteroscopy. In this case, the patient had no obvious clinical symptoms although the lesion protruded to the uterine cavity. Preoperative B-ultrasound repeatedly suggested abnormal manifestations in the uterine wall or uterine cavity. Two submucosal lesions were found only when the pressure of distention was reduced during hysteroscopy. The bottom wall of the cyst was preserved as part of the endometrium during treatment, followed by 3 months of sequential estrogen progesterone therapy. The pregnancy outcome was achieved through in vitro fertilization-embryo transfer. Through the retrospective analysis of this special case, we can deepen the understanding and diagnosis of cystic adenomyosis of uterus in a special location. When the abnormal manifestations of uterine wall or uterine cavity are repeatedly indicated by B-ultrasound, but no obvious abnormalities are found by hysteroscopy, the possibility of submucosal cystic adenomyosis should be considered, and the intrauterine lesions should be observed after the intrauterine pressure is reduced. In the treatment process, "fenestration" can also be adopted, followed by sequential therapy of estrogen plus progesterone to improve the pregnancy outcome.

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    Review
    Relationship of Uterine Microbiota and Female Reproductive Healthy Diseases
    ZHANG Ming-wei, QI Qian-rong, XIE Qing-zhen
    2022, 41 (3):  214-218.  doi: 10.12280/gjszjk.20220111
    Abstract ( 2759 )   HTML ( 215 )   PDF (789KB) ( 5707 )  

    The microbiota colonizing in the uterine cavity has been demonstrated by next-generation sequencing and microbiome technology in recent years. The changes of uterine microbiota are connected not only with physiological factors, but also with female reproductive healthy diseases. However, the core composition of uterine microbiota and the relationship between the host and the microbiota still remain unknown. The disorder of uterine microbiota could be related to the pathogenesis and pathophysiology of chronic endometritis, recurrent implantation failure, endometriosis and intrauterine adhesion, etc. However, there is not a consensus on the unified protocol to assess the dysbiosis of uterine microbiota and the optimal treatment protocol to adjust above dysbiosis. To some extent, probiotics or prebiotics using in vagina can assist to treat the dysbiosis of uterine microbiota and to improve the pregnancy outcome. In this review, we discussed the uterine microbiota and its relationship with female reproductive health.

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    The Role of Decidual Natural Killer Cells in Recurrent Pregnancy Loss and Related Treatment
    WANG Lu, LI Yang, DU Bo-tao
    2022, 41 (3):  219-224.  doi: 10.12280/gjszjk.20210615
    Abstract ( 2344 )   HTML ( 215 )   PDF (864KB) ( 5681 )  

    The incidence of recurrent pregnancy loss (RPL) is about 1%-5%. The immune microenvironment at the maternal-fetal interface has a vital impact on the pregnancy outcomes. Decidual natural killer (dNK) cells, as important immune cells at the maternal-fetal interface, can produce a variety of cytokines, regulate trophoblast cells invasion, promote uterine spiral arteries remodeling, and participate in the establishment of immune tolerance at the maternal-fetal interface in early pregnancy, so as to maintain pregnancy. However, the dNK cells are highly activated in RPL patients. The increased activity and changed function of dNK cells may affect the immune environment of pregnancy, thereby leading to pregnancy failure. At present, the therapeutic regimens that affects the microenvironment of the maternal-fetal interface by improving the activity and function of dNK cells, including intravenous immunoglobulin G and lipid emulsion, granulocyte colony-stimulating factor, glucocorticoid, mesenchymal stem cells, sildenafil citrate and Sirolimus have become new research directions in the treatment of RPL.

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    Factors of Recurrent Pregnancy Loss in Patients with Polycystic Ovary Syndrome
    YE Zi, MA Xiang
    2022, 41 (3):  225-229.  doi: 10.12280/gjszjk.20220075
    Abstract ( 2570 )   HTML ( 207 )   PDF (772KB) ( 5714 )  

    Multiple pathological factors of polycystic ovary syndrome (PCOS) are associated with recurrent pregnancy loss (RPL). Hyperinsulinemia and insulin resistance in PCOS patients can lead to pregnancy loss by interfering with the normal placental attachment. Metformin is clinically used to correct the abnormal metabolism related to hyperinsulinemia, and to reduce pregnancy loss. Excessive androgen in PCOS patients may lead to infertility, RPL and pregnancy complications. However, more high-quality clinical studies are needed to understand the relationship between excessive androgen and RPL. In addition, obesity and dyslipidemia increase the probability of RPL in PCOS patients. Dietary structure adjustment, lifestyle intervention and body weight management will reduce the adverse effects of obesity, and improve pregnancy outcomes. In this paper, we analyzed the factors of RPL in PCOS patients from insulin metabolism, glucolipid metabolism, androgen, homocysteine and vitamin D, in order to provide a clinical guidance for the fertility and assisted reproductive therapy of PCOS patients.

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    Biological and Clinical Characteristics of Obese PCOS Patients
    WANG Jiao-jian, LU Di, CHEN Ran-ran, SONG Dian-rong
    2022, 41 (3):  230-235.  doi: 10.12280/gjszjk.20220067
    Abstract ( 2899 )   HTML ( 207 )   PDF (817KB) ( 5682 )  

    Polycystic ovary syndrome (PCOS) is an endocrine and metabolic syndrome with highly heterogeneous manifestations. Obesity is one of the heterogeneous manifestations of PCOS, and more than 50% of PCOS patients are overweight or obese. Obese PCOS is characterized mainly by hyperandrogenism, central obesity and disturbed glucose and lipid metabolism, while non-obese PCOS is characterized mainly by abnormally elevated level of luteinizing hormone (LH). Although the endocrine metabolic abnormalities are present in both obese and non-obese PCOS, obesity exacerbates the disturbed glycolipid metabolism in PCOS patients. The obese PCOS also expresses the abnormality of lipid metabolism. In this review, we summarizethe clinical features, sex hormone levels and glycolipid metabolism of obese PCOS patients, so as to provide a reference for the new diagnosis and treatment of obese and non obese patients with PCOS.

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    The Effect and Mechanism of Epimedium (Icariin) on Male Reproductive System
    LI Cheng, CUI Yu-gui, QIN Lian-ju, HU Wen-jun
    2022, 41 (3):  236-239.  doi: 10.12280/gjszjk.20220051
    Abstract ( 4883 )   HTML ( 261 )   PDF (762KB) ( 5698 )  

    Epimedium is a commonly used traditional Chinese medicine. Icariin as a flavonoid extracted from Epimedium is the main active substance in Epimedium. It is found that Icariin has many functions, such as promoting the formation and activation of osteoblasts, regulating immunity, anti-aging, anti-inflammatory and so on. Clinically, Epimedium(Icariin) is used to treat many diseases of reproductive system, bone and joint, respiratory system, nervous system, cardiovascular system, immune system and other. This paper summarizes the effects and mechanisms of Epimedium(Icariin) on male reproductive system. Epimedium(Icariin) plays an androgen-like effect by itself, and promotes the synthesis and secretion of testicular testosterone. Icariin can promote the production of sperm, increase sperm density, improve sperm motility, and slow down reproductive decline by improving the microenvironment of spermatogenesis and antioxidation. In addition, Epimedium(Icariin) is also used to treat the erectile dysfunction and premature ejaculation by promoting penile erection.

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    Application of Mononuclear Cells in the Treatment of Reproductive System Diseases
    GAO Jing-yue, YU Xuan, ZANG Zhao-wen, DENG Xiao-hui
    2022, 41 (3):  240-244.  doi: 10.12280/gjszjk.20220034
    Abstract ( 2742 )   HTML ( 232 )   PDF (809KB) ( 5682 )  

    Mononuclear cells (MNCs) are a cell population of a variety of immune cells and pluripotent stem/progenitor cells. According to the source, they are mainly divided into umbilical cord blood mononuclear cells, bone marrow mononuclear cells and peripheral blood mononuclear cells. MNCs can inhibit apoptosis, and promote the differentiation and proliferation of stem cells in the damaged tissues. MNCs can also promote angiogenesis, and regulate the local immune microenvironment in vivo. The mechanisms of action may be related to homing, secretion and paracrine effects. The application researches of MNCs in the treatment of reproductive system diseases mainly involve premature ovarian failure, intrauterine adhesions and repeated implantation failure. The types of MNCs, tranplantation approaches and the development of clinical trials involved in studies are different. Exosomes, biological scaffolds and gene therapy are expected to become new exploration points for MNCs to treat female reproductive system diseases. However, there are still problems that cannot be ignored in the application of MNCs, including the effect of transplantation route and concentration on the treatment.

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    Research Progress in Human Chromosome 16p11.2 Microdeletion and Microduplication Syndrome
    YANG Xiao-mei, WU Qi-chang
    2022, 41 (3):  245-251.  doi: 10.12280/gjszjk.20220073
    Abstract ( 10648 )   HTML ( 356 )   PDF (819KB) ( 5803 )  

    The 16p11.2 syndrome is caused by the microdeletion or microduplication of chromosome 16p11.2 region, which is characterized by extensive heterogeneity and incomplete penetrance. The phenotype of 16p11.2 microdeletion is characterized by developmental retardation, intellectual disability, autism spectrum disorder (ASD), and morbid obesity, while the phenotype of 16p11.2 microduplication is characterized by ASD, schizophrenia, intellectual disability and microcephaly. Two core susceptible regions of 16p11.2 are a distal breakpoints (BP) at 28.8-29.0 Mb (BP2-BP3) of 220 kb and a proximal BP at 29.6-30.2 Mb (BP4-BP5) interval of 593 kb. Recurrent rearrangements of nonallelic homologous recombination between highly similar duplicated sequences lead to the deletion or duplication of 16p11.2. With the wide application of chromosome microarray analysis as a prenatal diagnostic technique, chromosomal microdeletions and microduplications are increasingly recognized. However, there is currently no effective therapeutic method for 16p11.2 syndrome. Therefore, a detailed understanding of the clinical manifestations, mechanism and candidate genes of 16p11.2 syndrome may provide a basis for genetic counseling.

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    Regulation of Bone Morphogenetic Protein 15 on Follicular Development and Its Relationship with Reproductive Endocrine Diseases
    CHEN Ming-li, ZHAO Xiao-li, FENG Wei-hua, XIA Tian
    2022, 41 (3):  252-257.  doi: 10.12280/gjszjk.20220023
    Abstract ( 2638 )   HTML ( 280 )   PDF (835KB) ( 5682 )  

    Bone morphogenetic protein 15 (BMP15) as an oocyte-secreted factor is vital to the regulation of follicle development. BMP15 promotes the development and maturation of oocytes by cooperating with amphiregulin and up-regulating the expression of cumulus expansion genes. BMP15 also promotes the proliferation and differentiation of granulosa cells by increasing the sensitivity of granulosa cells to FSH and stimulating the expression of Kit ligands in granulosa cells. BMP15 inhibits follicular atresia by regulating the expression of follicle apoptosis-related factors; and BMP15 can also mediate the regulation of steroid hormones by regulating the FSH receptor and the downstream Smad signaling pathways. The decreased expression or gene mutation of BMP15 may induce the apoptosis of granulosa cells, hinder the process of early follicle development and oogenesis, and mediate the pathogenesis of various diseases such as polycystic ovary syndrome and premature ovarian insufficiency. In this article, we review the roles of BMP15 in folliculogenesis and the research progress of BMP15-related reproductive endocrine diseases.

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    HIF-1α and Related Pathways in the Pathogenesis of Endometriosis
    WEN Ping-hua, WANG Xi-wen, ZHANG Wei, LIU Yi, LIU Heng-wei
    2022, 41 (3):  258-264.  doi: 10.12280/gjszjk.20220057
    Abstract ( 3135 )   HTML ( 197 )   PDF (1141KB) ( 5649 )  

    The pelvic hypoxic microenvironment is an important factor of the pathogenesis and development of endometriosis (EMs), in which the induced expression of hypoxia-inducible factor-1α (HIF-1α) participates in the angiogenesis, inflammatory response, as well as the proliferation, apoptosis, migration, invasion and epithelial-mesenchymal transition (EMT) of endometrial cells. More and more studies showed that the HIF-1α/Wnt/β-catenin, HIF-1α/lncRNA UBOX5-AS1, HIF-1α/ LATS1/YAP1 and GPER/HIF-1α/MMP-9 pathway participated in the migration, invasion and EMT; HIF-1α/TGF-β1/Smad and HIF-1α/EZH2/ANTXR2 in the cell adhesion; PI3K/AKT/HIF-1α, HIF-1α/ DUSP2/IL-6/STAT3 and HIF-1α/miR-210 pathway in the cell survive and proliferation; HIF-1α/miR-20a, miR-199a/HIF-1α/VEGF and HIF-1α/COUP-TFⅡ/Ang pathway in the angiogenesis of ectopic endometrial tissue. The recent studies also showed the characteristics of aerobic glycolysis in ectopic endometrial tissue and the autophage activated by HIF-1α. In this review, we summarized the effects of HIF-1α and its related signaling pathways in the EMs for further exploring the pathogenesis of EMs.

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