Research Progress of High-Risk Human Papillomavirus Negative Cervical Cancer

doi:10.12280/gjszjk.20220163

Abstract

Abstract:

Cervical cancer is the most common malignant tumor of female reproductive system, and the persistent infection of high-risk human papillomavirus (HR-HPV) is a necessary factor of cervical intraepithelial neoplasia and canceration. Currently, the early screening methods for cervical cancer include HPV testing, cervical exfoliation cytology and colposcopy. Clinically, most patients with cervical cancer are of HR-HPV positive, but less than 1% of cervical cancer patients are of HR-HPV negative. Compared with the HR-HPV positive cervical cancer patients, the HR-HPV negative cervical cancer patients have poor prognosis. Therefore, the most urgent issues are to find the pathogenesis of HR-HPV negative cervical cancer, and to explore the specific biomarkers and new therapeutic targets. In this paper, the pathogenesis, clinical characteristics and molecular biology research progress of HR-HPV negative cervical cancer are described, in order to provide new clinical ideas and basis for the diagnosis and treatment of HR-HPV negative cervical cancer.

Key words: Uterine cervical neoplasms, Papillomaviridae, Pathogenesis, Clinical characteristics, Molecular biology

LI Yu-lan, LIU Xiao, HAN Feng-jiao, YUE Ling, XU Fei-xue. Research Progress of High-Risk Human Papillomavirus Negative Cervical Cancer[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(4): 342-346.

Figures/Tables 1

References 34

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分类	占宫颈腺癌比例	HR-HPV阴性率
普通型	75%	0%~20%
黏液型-肠型	8%	0%~17%
绒毛管型	3%~6%	0%
黏液型-印戒细胞型	罕见	0%
子宫内膜样型	罕见	100%
胃型	未知	100%
中肾管型	罕见	100%
透明细胞型	2%~7%	72%
浆液性	非常罕见	70%

分类	占宫颈腺癌比例	HR-HPV阴性率
普通型	75%	0%~20%
黏液型-肠型	8%	0%~17%
绒毛管型	3%~6%	0%
黏液型-印戒细胞型	罕见	0%
子宫内膜样型	罕见	100%
胃型	未知	100%
中肾管型	罕见	100%
透明细胞型	2%~7%	72%
浆液性	非常罕见	70%