Abstract:

Cervical cancer, endometrial cancer and ovarian cancer are the three most common malignant tumors in gynecology, and the incidences are on the rise in all ages in recent years. The gynecological malignant tumors have become a serious threat to women′s health in China. Although the application of a variety of targeted drugs has significantly prolonged the survival of patients, cervical cancer, endometrial cancer and ovarian cancer are still a group of diseases that cannot be accurately diagnosed and treated. MiR-17-92 gene cluster, as the earliest identified miRNA family of oncogene, has been widely concerned about its mechanism. As a member of the miR-17-92 gene cluster, miR-20a can play a post-transcriptional regulatory role by reducing or increasing the expression, thus affecting the downstream gene pathway, regulating the proliferation, invasion, and metastasis of malignant tumor cells, and finally achieving the occurrence and progress of malignant tumors. According to the current research progress, the specific increase of miR-20a expression in cervical cancer, endometrial cancer and ovarian cancer is usually related to the malignant progress of the disease. This article reviews the research progress of miR-20a in the pathogenesis of three common gynecological malignant tumors.

Key words: MiR-20a, Endometrial neoplasms, Uterine cervical neoplasms, Ovarian neoplasms, MiR-17-92 gene cluster, MicroRNAs