Abstract:

The rapid development of assisted reproductive technology has enabled many infertile patients to get successful pregnances through in vitro fertilization and embryo transfer and its derivative technology. However, there are still some patients who have failed to obtain a clinical pregnancy after transferring high-quality embryos for many times. This is called repeated implantation failure (RIF). RIF is a difficult problem in assisted reproductive technology, which increases the economic burden of patients and aggravates their physical and mental trauma. How to improve embryo quality, to intervene maternal factors (such as improving thin endometrium, improving endometrium receptivity, inhibiting uterine contraction, improving hypercoagulability, immunosuppressive therapy) and to change embryo transfer methods so as to improve pregnancy outcomes, are hot spots in clinical research. The research progress of clinical treatment strategies of RIF due to different etiologies was reviewed in order to provide reference and treatment ideas for clinical workers.

Key words: Infertility, Embryo implantation, Embryo transfer, Endometrium, Therapy, Pregnancy outcome