Research Progress of Ferroptosis in Pathogenesis of Polycystic Ovary Syndrome

doi:10.12280/gjszjk.20240328

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common metabolic disorder of the reproductive system in women of adolescent and childbearing age. In addition to ovulatory dysfunction, menstrual dysfunction and infertility, most patients suffer from endocrine abnormalities such as insulin resistance (IR), hyperandrogenemia (HA) and abdominal obesity. Ferroptosis, a highly iron-dependent programmed cell death mediated by the lipid peroxidation and the imbalance in the oxidative-antioxidant system is a hot research topic in reproductive medicine. The relevance of ferroptosis in PCOS has received much attention in recent years, and recent studies suggest that ferroptosis may be involved in the regulation of PCOS-associated metabolic disorders and affect reproductive function in women with PCOS by disrupting oocyte quality and uteroplacental function. To further enrich and improve the system of diagnosis, prevention, and prognosis assessment of PCOS, we summarize the mechanisms related to ferroptosis, systematically discusses the correlation between ferroptosis and the pathophysiology of PCOS, and its research progress in the treatment of PCOS.

Key words: Ferroptosis, Cell death, Iron overload, Polycystic ovary syndrome, Infertility, female

LI Xuan-ang, WANG Ting-ting, XIANG Shan, ZHAO Shuai, LIAN Fang. Research Progress of Ferroptosis in Pathogenesis of Polycystic Ovary Syndrome[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(5): 425-429.

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