Research Progress in Single-Cell Omics of Human Endometrium

doi:10.12280/gjszjk.20240094

Abstract

Abstract:

The expression and function of various subtypes of cells in the endometrium are crucial for maintaining normal endometrial function and providing an environment for embryo implantation. In recent years, the single-cell omics has gradually become an important tool for the basic research and clinical application related to endometrium, as it can perform the high-throughput sequencing of endometrium from different sources and stages at the single-cell level. This article provides a systematic review of existing studies on the single-cell omics related to the endometrium, including the physiological status of the endometrium, as well as the single-cell differences and intercellular interactions in pathological conditions such as recurrent spontaneous abortion, endometriosis, adenomyosis, thin endometrium, intrauterine adhesions, repeated implantation failures and endometrial cancer. The deeper understanding of the application of single-cell omics of endometrium is helpful for us to reveal the pathophysiological mechanisms of the endometrium-related diseases.

Key words: Endometrium, Single-cell analysis, High-throughput nucleotide sequencing, Receptivity, Embryo implantation

JIANG Le-ran, ZHANG Yuan, WANG Lin, DIAO Fei-yang. Research Progress in Single-Cell Omics of Human Endometrium[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(3): 216-221.

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