Effect of Growth Factors in Follicular Fluid on Oocyte Development and Quality

doi:10.12280/gjszjk.20240527

Abstract

Abstract:

Follicular fluid is composed of the plasma that crosses the blood-follicle barrier and the active substances secreted by granulosa cells and theca cells. It contains various growth factors that significantly influence the development and quality of oocytes, including members of the transforming growth factor-β superfamily, insulin-like growth factors, tumor necrosis factor-α, vascular endothelial growth factors, interleukins (IL) and others. They regulate cell growth and function by binding to specific, high-affinity receptors of membrane, thereby affecting oocyte maturation and quality, as well as subsequent fertilization, embryonic development, and pregnancy outcomes. The concentrations of growth factors in follicular fluid may be related to oocyte quality. These factors such as bone morphogenetic protein-15 (BMP-15), growth differentiation factor-9 (GDF-9) and IL-6 have garnered significant attention. Although the relationship between growth factors and oocyte quality remains controversial, future research will reveal their exact connection, providing more accurate methods for predicting oocyte quality and embryonic development in clinical practice.

Key words: Follicular fluid, Intercellular signaling peptides and proteins, Transforming growth factor beta, Interleukins, Oocyte quality

WANG Yun-feng, HOU Hai-yan, WANG Jian-mei. Effect of Growth Factors in Follicular Fluid on Oocyte Development and Quality[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(2): 137-143.

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