Research Progress on 5-Hydroxytryptamin and Adverse Pregnancy Outcomes

doi:10.12280/gjszjk.20240532

Abstract

Abstract:

5-hydroxytryptamin (5-HT) as a neurotransmitter participates in the regulation of mood, appetite and blood circulation by the interaction with its receptors. 5-HT also plays a significant role in maintaining placental function, oocyte maturation, and early embryonic development. Studies have shown that the abnormal level of 5-HT during pregnancy is closely associated with the adverse pregnancy outcomes such as hyperemesis gravidarum, pregnancy-induced hypertension, and gestational diabetes. The elevated level of the 5-HT₃ receptor during pregnancy can increase the risk of nausea and vomiting of pregnancy or hyperemesis gravidarum. The abnormal levels of 5-HT₁, 5-HT₂, and 5-HT₇ receptors during pregnancy can raise the risk of pregnancy-induced hypertension and gestational diabetes. This article aims to elucidate the specific mechanisms that 5-HT affects the adverse pregnancy outcomes, and to provide new potential insights for the future clinical prevention and treatment of adverse pregnancy outcomes.

Key words: Serotonin, Receptors, serotonin, Hyperemesis gravidarum, Hypertension, pregnancy-induced, Diabetes, gestational

LIU Yue, GAO Jing-shu, WANG Yu, FENG Jia-xing, GE Hang, WU Xiao-ke. Research Progress on 5-Hydroxytryptamin and Adverse Pregnancy Outcomes[J]. Journal of International Reproductive Health/Family Planning, 2025, 44(2): 155-160.

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