Abstract: Cystic fibrosis（CF）is a very common and deadly euchromosome recessive genetic disease
among white people. It is a kind of genetic disease caused by cystic fibrosis transmembrane conductance
regulator’s (CFTR) genic mutation. Cystic fibrosis transmembrane conductance regulator’s genic mutation often
shows with congenital bilateral absence of the vas deferens (CBAVD)，congenital unilateral absence of the vas
deferens (CUAVD) and the low quality of sperm in male infertility. Intracytoplasmic sperm injection technique
gives those patients the chance of producing generations but it can also inherit their generations with mutation
gene preimplantation genetic diagnosis （PGD）and genetic risk analysis can avoid a embryo with genetic
mutation to plant in uterus and improve the quality of fertility.

Key words: Cystic fibrosis transmembrane conductance regulator, Genes, Infertility, male, Cystic fibrosis, Preimplantation diagnosis