Abstract: Genomic imprinting means the differential expression of allele genes which derivatived from either parents. The relationship between assisted reproductive technology（ＡＲＴ） and abnormalities in genomic imprinting needs further study in the field of ferｔｉｌｉｔｙ ｓａｆｅｔｙ． ＡＲＴ ｃｏｍｐｒｉｓｅｓ ｓｅｖｅｒａｌ ｓｔｅｐｓ， ｉｎｃｌｕｄｉｎｇ ｔｈｅ ｃｏｎｔｒｏｌｌｅｄ ｏｖａｒｉａｎ ｓｔｉｍｕｌａｔｉｏｎ （ＣＯＳ）， ｉｎ ｖｉｔｒｏ ｆｅｒｔｉｌｉｚａｔｉｏｎ （ＩＶＦ）/ｉｎｔｒａ?鄄ｃｙｔｏｐｌａｓｍｉｃ ｓｉｎｇｌｅ ｓｐｅｒｍ ｉｎｊｅｃｔｉｏｎ （ＩＣＳＩ）， ｉｎ ｖｉｔｒｏ ｍａｔｕｒａｔｉｏｎ （ＩＶＭ）， ｅｍｂｒｙｏ ｔｒａｎｓｆｅｒ （ＥＴ）， ｅｔｃ． Ｉｔ ｉｓ ｎｏｔ ｃｌｅａｒ ｗｈｉｃｈ ｓｔｅｐ ｏｆ ＡＲＴ ａｎｄ ｈｏｗ ｔｏ ｇｉｖｅ ｒｉｓｅ ｔｏ ａｂｎｏｒｍａｌｉｔｉｅｓ ｉｎ ｇｅｎｏｍｉｃ ｉｍｐｒｉｎｔｉｎｇ． Ｏｎ ｔｈｅ ｂａｓｉｓ ｏｆ ｉｎｆｅｒtility, COS, IVM, IVF/ICSI and embryo manipulation could lead to abnormalities in genomic imprinting to varying degrees, from a different perspective.

Key words: Reproductive techniques, assisted, Genetic markers, DNA methylation, Superovulation, Fertilization in vitro, Embryo transfer, Sperm injections, intracytoplasmic