Journal of International Reproductive Health/Family Planning ›› 2012, Vol. 31 ›› Issue (6): 491-494.
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GAI Ling,ZHANG Mei-hua,GAI Ping,LIU Xia
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Abstract: Ｄｅｐｏ－Ｐｒｏｖｅｒａ Ｃｏｎｔｒａｃｅｐｔｉｖｅ ｉｎｊｅｃｔｉｏｎ （Ｄｅｐｏｔ ｍｅｄｒｏｘｙｐｒｏｇｅｓｔｅｒｏｎｅ ａｃｅｔａｔｅ，ＤＭＰＡ） ｉｓ ａ ｐｒｏｇｅｓｔｉｎ－ｏｎｌｙ ｃｏｎｔｒａｃｅｐｔｉｖｅ ｔｈａｔ ｐｒｏｖｉｄｅｓ ｈｉｇｈｌｙ ｅｆｆｅｃｔｉｖｅ，ｐｒｉｖａｔｅ，ｌｏｎｇ－ａｃｔｉｎｇ ｃｏｎｔｒａｃｅｐｔｉｏｎ． Ｂｕｔ，ｉｔ ｍａｙ ｒｅｄｕｃｅ ｂｏｎｅ ｍｉｎｅｒａｌ ｄｅｎｓｉｔｙ （ＢＭＤ） ａｎｄ ｉｎｃｒｅａｓｅ ｏｓｔｅｏｐｏｒｏｓｉｓ ｒｉｓｋ． Ｉｎ ２００４，ｔｈｅ Ａｍｅｒｉｃａｎ Ｆｏｏｄ ａｎｄ Ｄｒｕｇ Ａｄｍｉｎｉｓｔｒａｔｉｏｎ （ＦＤＡ） ｉｓｓｕｅｄ ａ Ｂｌａｃｋ Ｂｏｘ Ｗａｒｎｉｎｇ “ｗｏｍｅｎ ｗｈｏ ｕｓｅ Ｄｅｐｏ－Ｐｒｏｖｅｒａ Ｃｏｎｔｒａｃｅｐｔｉｖｅ ｉｎｊｅｃｔｉｏｎ ｍａｙ ｌｏｓｅ ｓｉｇｎｉｆｉｃａｎｔ ｂｏｎｅ ｍｉｎｅｒａｌ ｄｅｎｓｉｔｙ． Ｂｏｎｅ ｌｏｓｓ ｉｓ ｇｒｅａｔｅｒ ｗｉｔｈ ｉｎｃｒｅａｓｉｎｇ ｄｕｒａｔｉｏｎ ｏｆ ｕｓｅ ａｎｄ ｍａｙ ｎｏｔ ｂｅ ｃｏｍｐｌｅｔｅｌｙ ｒｅｖｅｒｓｉｂｌｅ．” Ｉｎ ２０１０，ＦＤＡ ｅｍｐｈａｓｉｚｅｄ ａｇａｉｎ ｔｈｅ ｅｆｆｅｃｔ ｏｆ ＤＭＰＡ ｏｎ ＢＭＤ ｏｎ ｔｈｅｉｒ ｗｅｂｓｉｔｅ． Ｔｈｅｒｅｆｏｒｅ，ｒｅｓｅａｒｃｈｅｒｓ ｃｏｎｃｅｒｎ ｗｈｅｔｈｅｒ ＤＭＰＡ ｉｓ ｈａｒｍｆｕｌ ｆｏｒ ｂｏｎｅ ｈｅａｌｔｈ． Ｅｆｆｅｃｔ ｏｆ ＤＭＰＡ ｏｎ ｂｏｎｅ ｈｅａｌｔｈ ｗａｓ ｒｅｖｉｅｗｅｄ．
GAI Ling;ZHANG Mei-hua;GAI Ping;LIU Xia. Progestin-only Contraceptive-depot，Medroxyprogesterone Acetate Contraceptive Injection，and Skeletal Health[J]. Journal of International Reproductive Health/Family Planning, 2012, 31(6): 491-494.
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