Abstract: Asthenospermia is one kind of male infertility, about 19% in total cases, which caused by defects in sperm motility. Generally, the energy for sperm motility fundamentally comes from the oxidative phosphorylation of mitochondrial respiratory chain. Thus, any factors related mitochondrial metabolism, such as oxidative stress, cell apoptosis as well as Ca2+ cycle, will have significant influences on sperm motility. Herein, we reviewed the research advances on mitochondrial metabolism and sperm motility.

Key words: Sperm motility, Mitochondria, Oxidative stress, Apoptosis, Ca2+cycle