Journal of International Reproductive Health/Family Planning ›› 2013, Vol. 32 ›› Issue (5): 344-348.

• 综述 • Previous Articles     Next Articles

Progress in Medical Treatment of Abnormal Uterine Bleeding

HU Yan-jun,ZHU Yi-min,HUANG He-feng   

  1. Department of Reproductive Endocrinology(HU Yan-jun,ZHU Yi-min),Department of Obstetric and Gynecology(HUANG He-feng),Women's Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-09-15 Online:2013-09-15

Abstract: FIGO Menstrual Disorders Group (FMDG) put forward that the abnormal uterine bleeding (AUB) was a suitable overarching term for the symptom of disturbed menstrual bleeding,and that the terms ′menorrhagia′ and ′disfunctional uterine bleeding (DUB)′ should be discarded . The heavy menstrual bleeding (HMB) should be used to replace the term of menorrhagia for the symptom of excess menstrual bleeding. FMDG classified the AUB according to the causes using the PALM-COEIN system. Medical management should be the initial treatment for AUB of COEIN causes, including multi-dose regimens of combined oral contraceptives or oral progestins,NSAIDs,tranexamic acid and the levonorgestrel-releasing intrauterine system (LNG-IUS). LNG-IUS is the most effective medical treatment for idiopathic HMB. Desmopressin is effective in management of HMB in women with bleeding disorders. Metformin is applied to regulate the menstrual cycle in PCOS women. And Metformin has therapeutical effect on the endometrial hyperplasia combined with progestin-resistant. Moreover, there are more choices for HMB treatment, such as the new four-phasic estradiol valerate/dienogest contraceptive pills, the modified-release formulation of tranexamic acid, the combined contraceptive vaginal ring, and vaginal danazol.

Key words: Uterine hemorrhage, Functional uterine bleeding, Drug therapy, Therapy