Abstract: Hormone replacement therapy （HRT） is of choice for menopause population, to alleviate effectively those symptoms of menopause and to prevent the postmenopausal osteoporosis. However, it is necessary that HRT be personalized. The principles of personalized HRT are based on many aspects, such as symptoms, age, baseline diseases, indications and contraindications. When HRT is prescribed, many other aspects should be considered, including preparation and dose of HRT drug, route of administration, and the best ′treatment window′. The HRT should start at minimum dose with the best effect of treatment.

Key words: Menopause, Hormone replacement therapy, Osteoporosis, postmenopausal, Individuality