Research Progress of GnRHa Downregulated Hormone Replacement Treatment Cycle in Frozen-Thawed Embryo Transfer

doi:10.12280/gjszjk.20220236

Abstract

Abstract:

Freeze-thawed embryo transfer (FET) has been widely used in clinical practice due to its advantages of the increasing cumulative pregnancy rate and the reducing risk of ovarian hyperstimulation. The quality of transplanted embryos, endometrium and their synchronization are the key factors of FET success. The common clinical schemes of endometrial preparation include natural cycle, controlled ovarian stimulation, hormone replacement treatment (HRT) and downregulation HRT. For the most women, the above conventional schemes can be used for FET endometrial preparation. For special patients such as the patients with polycystic ovary syndrome, endometriosis, adenomyosis, recurrent implantation failure and thin endometrium, the clinical effect of conventional endometrial preparation scheme is poor. The pituitary downregulation method is based on the GnRHa pituitary downregulation, and hormone replacement therapy is applied to prepare the endometrium, suggesting that the downregulated HRT cycle can effectively improve the pregnancy outcome of the above special population compared with the conventional endometrial preparation scheme. This paper reviews the related mechanisms of GnRHa down regulation of HRT cycle and its suitable population.

Key words: Fetal tissue transplantation, Gonadotropin-releasing hormone, Hormone replacement therapy, Pregnancy outcome, Frozen-thawed embryo transfer, Endometrial preparation scheme, Down-regulation

DUAN Xia, WANG Zhi-hong. Research Progress of GnRHa Downregulated Hormone Replacement Treatment Cycle in Frozen-Thawed Embryo Transfer[J]. Journal of International Reproductive Health/Family Planning, 2022, 41(5): 419-424.

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