Abstract: Hormone replacement therapy （HRT） can effectively alleviate those symptoms of female menopausal，and prevent the postmenopausal osteoporosis and some senile chronic diseases. There are a large number of menopausal women in China. It's necessary for most of gynecologists to have an exact recognition on HRT. And for the clinical operation，they should provide the right instruction on HRT for the individual patient. However，both patients and doctors are concerned about safety of HRT. Recent evidences from clinical research showed that the HRT safety was significantly related to the enable timing and individualized dosage regimen. HRT should be started in the window period，while the individualized dosage regimen should be based on the different age，specific symptoms，the family disease history and baseline diseases. The Standardized follow-up is necessary during treatment.

Key words: Menopause, Hormone replacement therapy, Osteoporosis, postmenopausal, Individuality, Window period