Abstract: Objective：To investigate and analyze the status of AIDS prevention knowledge in Chinese university, and to explore those possible factors, so as to provide the reference for improving AIDS prevention and health education in university. Methods：A total of 2 500 undergraduates were selected by using the stratified random sampling method, and epidemiologically surveyed using the questionnaires designed by ourselves. Results：The average score of AIDS prevention knowledge was 74.19±14.88, boys had higher mean score than girls （χ2=16.516, P=0.000） while seniors had higher mean score than those lower grades （Z=7.765, P=0.000）. Interestingly, the group of only-child had higher score than the group of non-only-child（χ2=7.639, P=0.006）, and students from different majors had different scores（χ2=17.718, P=0.013）. After corrected by the unconditional Logistic regression, girls had lower score than boys（OR=0.686, 95%CI: 0.548-0.860）. Those students from the first grade had lower scores than those from the second grade （OR=1.865, 95%CI: 1.455-2.390）, the third grade （OR=2.671, 95%CI: 2.033-3.509）and the fourth grade （OR=2.618, 95%CI: 1.918-3.573）. Conclusions： Female students, low-grade students and non-only-child students should be important groups of the AIDS education in Chinese universities, to improve their knowledge on the AIDS prevention and self-care.

Key words: Students, Acquired immunodeficiency syndrome, Questionnaires, Preventive medicine