Journal of International Reproductive Health/Family Planning ›› 2014, Vol. 33 ›› Issue (4): 297-300.

• 综述 • Previous Articles     Next Articles

MicroRNA and Cervical Cancer

LI Pu,LIU Jun-yan,KONG Fan-ming,YIN Li-rong   

  1. Department of Gynecologic Oncology,Tianjin Central Hospital of Gynecology Obstetrics,Tianjin 300100,China(LI Pu);Department of Pathogeny Biology,Tianjin Medical University,Tianjin 300070,China(LIU Jun-yan);Department of Oncology,First Teaching Hospital of Tianjin University of TCM,Tianjin 300193,China(KONG Fan-ming);Department of Obstetrics and Gynecology,The Second Hospital of Tianjin Medical University,Tianjin 300210,China(YIN Li-rong)
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-07-15 Online:2014-07-15
  • Contact: YIN Li-rong

Abstract: MicroRNA (miRNA), a class of endogenous small non-coding regulatory RNAs, regulate the expression of target genes by pairing with its 3′untranslated regions (3′UTR) to induce the inhibited translation or mRNA degression. Mature miRNA may interfere with multiple biological processes involved in tumorigenesis such as cell proliferation, cell cycle, apoptosis, angiogenesis, invasion and metastasis. Multiple studies showed that the aberrant expression of miRNA, as novel potential makers, could provide numerous promising merits in diagnostic, pathological and therapeutic targets in cervical cancer.

Key words: MicroRNAs, Uterine cervical neoplasms, Carcinoma, Diagnosis, Drug resistance, neoplasm