Abstract: Objective：To observe the effects of Penyanxiao clysis fluid on hemorheology in the rabbit model with microcirculation disorder. Methods：Thirty rabbits were randomly divided into 5 groups as follows, the control group, the model group, the low-dose treatment group（treated with clysis fluid 5.0 g/kg)，the high-dose treatment group (treated with clysis fluid 10.0 g/kg） and the Chuanxiongqin group as positive control. The rabbit model was developed with the macromolecule dextran. The blood viscosity and plasma viscosity were tested using the FASCO-300 automatic monitor, HCT was detected by the Venturi method, the blood sedimentation by the Wintrobe method, and the hemorheological index was then calculated. Results：Compared with the model group, two treatment groups had the decreased blood viscosity, plasma viscosity and the whole blood reductive viscosity（Ｐ＜０．０１）. The cell aggregation and thrombosis were reduced, and the erythrocyte deformation index and HCT improved, which suggested the therapeutical effects of Penyanxiao clysis fluid with dose-dependence on the microcirculation disorder induced by macromolecule dextran. The erythrocyte deformation index in the low-dose treatment group was better than that in the Chuanxiongqin group（Ｐ＜０．０１）. Conclusions：Penyanxiao clysis fluid can significantly improve the microcirculation and hemorheological indexes in the rabbit model with microcirculation disorder.

Key words: Penyanxiao Enema Liquid, Microcirculation, Rabbits, Animal experimentationy