Abstract: The epigenetic profile of germ cells is defined by the modifications of DNA and chromatin. Meanwhile，those modifications dynamically change during germ cell development. Epigenetic modifiers and their regulatory proteins，such as DNA methyltransferases，histone modification enzymes，B-lymphocyte maturation-induced protein 1（BLIMP1） and calmodulin-dependent protein kinase 4（Camk4），play the crucial roles in reprogramming of the germ-cell genome，repression and activation of the downstream target genes，and germ-cell specific events，for example，germ cell development，regulation of meiosis，chromosome pairing and genomic integrity，and so on, during the germ-cell genesis and development. Herein, the research progress of the genesis and development of mammalian germ-cell, and their epigenetic regulation，were reviewed.

Key words: Mammals, Germ cells, Epigenesis, genetic