Abstract: Translocation carriers usually had normal phenotype, but they generally had abnormal pregnancy history, such as abortion, dead-birth, fetal anomaly and hypophrenia mainly due to those embryos with the unbalanced translocation and the deletion or repetition of chromosome fragment（ｓ） which generated during the fertilization. Normal and/or balanced embryos can be selected for transfer by ART and PGD for those translocation carriers to prevent the abnormal pregnancy. This review introduced the conception, classification and indication of PGD, the probability of reciprocal translocation carriers and Robertsonian translocation carriers to get a normal baby. The principles, advantages and disadvantages, and practical issues and value of common PGD techniques for those translocation carriers were also discussed, including FISH, SKY, CGH, aCGH, SNP and NGS.

Key words: Translocation, genetic, Preimplantation diagnosis, Aneuploidy