Abstract: Objective：To investigate the effect of ovarian stimulation with HMG combined with low-dose of hCG on those inferlity patients with hypogonatropic hypogonadism and amenorrhea. Methods:  Four infertility patients with hypogonatropic hypogonadism and amenorrhea were treated with HMG and low-dose of hCG for two cycles after one treatment with only HMG for four cycle, as for their ovarian stimulation. Follicular development was monitored by vaginal ultrasound-B and serum sexual hormone. Results: Totally, there were 4 cycles of only HMG treatment, and 8 cycles of HMG+hCG treatment. Compared with the only HMG cycles, the HMG+hCG cycles had the number of dominant follicles between 1 and 4, the cumulating pregnancy rate 50%, no moderate and severe OHSS, and a term birth for every patient.  Conclusions: The protocol of HMG combined with low-dose of hCG can be tried in those infertility patients with hypogonatropic hypogonadism for ovarian stimulation. However, the safety and efficiency of this combined protocol should be tested by other clinical trials and large samples.

Key words: Hypogonadotropic hypogonadism, Amenorrhea, Hypothalamic diseases, Menotropins, Chorionic gonadotropin, Ovulation induction