Abstract: Objective：To explore the effects of anxiety disorder on the clinical outcomes of in-vitro fertilization-embryo transfer (IVF-ET). Methods: The anxiety level was assessed and analyzed by the Hamilton anxiety scale (HAMA) for 210 patients undergoing IVF-ET treatment. They were then divided into three groups: the A group (mild anxiety, n=55), the B group (moderate anxiety, n=105) , and the C group (severe anxiety, n=50). Several parameters of the three groups, including the number of retrieved oocyte, 2PN rate, the rate of high-qualified embryo, clinical pregnant rate and early abortion rate, were compared. Results: The retrieved oocyte number, 2PN rate, the rate of high-qualified embryos and clinical pregnant rate in the A group were significantly higher than those in the B group and the C group (P＜0.05). The clinical pregnancy rate in the B group was significantly higher than that in the C group (P＜0.05). Conclusions: The heavier the anxiety, the worse the effect on the outcome of IVF-ET. The anxiety level should be evaluated in IVF patients if possible, and treated with appropriate psychological intervention in those patients with moderate and severe anxiety, so as to improve their outcomes of IVF-ET.

Key words: Anxiety, Fertilization in vitro, Embryo transfer, Pregnancy outcome