Research on the Correlation between Polycystic Ovary Syndrome and Anxiety and Depression Disorders

doi:10.12280/gjszjk.20240332

Abstract

Abstract:

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine and metabolic disease in women of childbearing age. Clinically, it is accompanied by a series of facial and physical symptoms such as obesity, acne, hirsutism and black skin, reproductive problems such as infrequent ovulation, menstrual disorders and even infertility, and metabolic disorders such as insulin resistance and hyperandrogenism. Compared with the normal population, PCOS patients are more prone to negative emotions and emotional disorders, with anxiety and depression disorders being the most common. Epidemiological studies have shown that anxiety and depression disorders are highly prevalent in patients with PCOS. In addition, increasing evidence suggests that PCOS is closely related to anxiety and depression disorders in terms of pathogenesis, with many similar clinical manifestations or pathogenic factors. PCOS often has a causal relationship and mutual influence with anxiety and depression disorders, forming a vicious cycle. Therefore, it is called for early identification and intervention of negative emotions in PCOS patients.

Key words: Polycystic ovary syndrome, Mood disorders, Depression, Anxiety, Biogenic monoamines

QIAO Xin-yue, TAO Ai-lin, FENG Xiao-ling, CHEN Lu. Research on the Correlation between Polycystic Ovary Syndrome and Anxiety and Depression Disorders[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(6): 506-511.

References 46

[1]	Yang R, Li Q, Zhou Z, et al. Changes in the prevalence of polycystic ovary syndrome in China over the past decade[J]. Lancet Reg Health West Pac, 2022,25:100494. doi: 10.1016/j.lanwpc.2022.100494.
[2]	Agajani Delavar M, Esmaeilzadeh S, Farhadi Z, et al. A policy brief on improving the lifestyle of women with polycystic ovary syndrome[J]. Caspian J Intern Med, 2024, 15(1):176-183. doi: 10.22088/cjim.15.1.21.
[3]	中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 抑郁症基层诊疗指南(2021年)[J]. 中华全科医师杂志, 2021, 20(12):1249-1260. doi: 10.3760/cma.j.cn114798-20211020-00778.
[4]	闫璐, 李政, 韩兴哲, 等. 抑郁症与焦虑障碍共病患者性格特点与干预后认知、执行功能改善效果[J]. 河北医药, 2023, 45(4):626-628,633. doi: 10.3969/j.issn.1002-7386.2023.04.036.
[5]	GBD 2019 Mental Disorders Collaborators. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019[J]. Lancet Psychiatry, 2022, 9(2):137-150. doi: 10.1016/S2215-0366(21)00395-3. pmid: 35026139
[6]	Alur-Gupta S, Chemerinski A, Liu C, et al. Body-image distress is increased in women with polycystic ovary syndrome and mediates depression and anxiety[J]. Fertil Steril, 2019, 112(5):930-938.e1. doi: 10.1016/j.fertnstert.2019.06.018. pmid: 31395311
[7]	Yadav S, Delau O, Bonner AJ, et al. Direct economic burden of mental health disorders associated with polycystic ovary syndrome: Systematic review and meta-analysis[J]. Elife, 2023,12:e85338. doi: 10.7554/eLife.85338.
[8]	Cooney LG, Lee I, Sammel MD, et al. High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis[J]. Hum Reprod, 2017, 32(5):1075-1091. doi: 10.1093/humrep/dex044.
[9]	Karjula S, Morin-Papunen L, Auvinen J, et al. Psychological Distress Is More Prevalent in Fertile Age and Premenopausal Women With PCOS Symptoms: 15-Year Follow-Up[J]. J Clin Endocrinol Metab, 2017, 102(6):1861-1869. doi: 10.1210/jc.2016-3863. pmid: 28323926
[10]	Yin X, Ji Y, Chan C, et al. The mental health of women with polycystic ovary syndrome: a systematic review and meta-analysis[J]. Arch Womens Ment Health, 2021, 24(1):11-27. doi: 10.1007/s00737-020-01043-x.
[11]	Rudnicka E, Suchta K, Grymowicz M, et al. Chronic Low Grade Inflammation in Pathogenesis of PCOS[J]. Int J Mol Sci, 2021, 22(7):3789. doi: 10.3390/ijms22073789.
[12]	商婷婷, 庄子荀, 马桦, 等. 从“脾为之卫”理论探析巨噬细胞极化在PCOS慢性低度炎症中的作用[J]. 中国实验方剂学杂志, 2024, 30(9):211-218. doi: 10.13422/j.cnki.syfjx.20241296.
[13]	Zhou Y, Wang C, Lan X, et al. Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine[J]. J Neuroinflammation, 2021, 18(1):200. doi: 10.1186/s12974-021-02245-5.
[14]	Liu M, Li Y, Liu X. Serum tumor necrosis factor-α, interleukin-1β, interleukin-6, and interleukin-17 relate to anxiety and depression risks to some extent in non-small cell lung cancer survivor[J]. Clin Respir J, 2022, 16(2):105-115. doi: 10.1111/crj.13457.
[15]	Koo JW, Russo SJ, Ferguson D, et al. Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior[J]. Proc Natl Acad Sci U S A, 2010, 107(6):2669-2674. doi: 10.1073/pnas.0910658107.
[16]	Chen Y, Zhang Y, Wang J, et al. Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic α7nAchR/JAK2/STAT3/NF-κB pathway in rats exposed to chronic unpredictable mild stress[J]. CNS Neurosci Ther, 2023, 29(9):2634-2644. doi: 10.1111/cns.14207.
[17]	苏红. 抑郁症的发病机制与常用抗抑郁药物的研究现状及进展[J]. 现代医学与健康研究(电子版), 2023, 7(21):16-19. doi: 10.3969/j.issn.2096-3718.2023.21.006.
[18]	林洁筠, 段阳, 龙淼青, 等. 柴胡疏肝散在抗抑郁治疗中的药效物质与作用机制研究进展[J]. 中国实验方剂学杂志, 2024, 30(10):246-257.doi:10.13422/j.cnki.syfjx.20240117.
[19]	Kim JW, Suzuki K, Kavalali ET, et al. Ketamine: Mechanisms and Relevance to Treatment of Depression[J]. Annu Rev Med, 2024, 75:129-143. doi: 10.1146/annurev-med-051322-120608.
[20]	Guo W, Yao X, Cui R, et al. Mechanisms of paeoniaceae action as an antidepressant[J]. Front Pharmacol, 2022,13:934199. doi: 10.3389/fphar.2022.934199.
[21]	曹云霞, 王玉蓉. 多囊卵巢综合征与心理因素的关系[J]. 中国实用妇科与产科杂志, 2007, 23(9):675-678. doi: 10.3969/j.issn.1005-2216.2007.09.008.
[22]	Sarkisian KI, Ho L, Yang J, et al. Neuroendocrine, neurotransmitter, and gut microbiota imbalance contributing to potential psychiatric disorder prevalence in polycystic ovarian syndrome[J]. F S Rep, 2023, 4(4):337-342. doi: 10.1016/j.xfre.2023.08.009.
[23]	Xu Y, Qiao J. Association of Insulin Resistance and Elevated Androgen Levels with Polycystic Ovarian Syndrome (PCOS): A Review of Literature[J]. J Healthc Eng, 2022,2022:9240569. doi: 10.1155/2022/9240569.
[24]	Armanini D, Boscaro M, Bordin L, et al. Controversies in the Pathogenesis, Diagnosis and Treatment of PCOS: Focus on Insulin Resistance, Inflammation, and Hyperandrogenism[J]. Int J Mol Sci, 2022, 23(8):4110. doi: 10.3390/ijms23084110.
[25]	Wang J, Yin T, Liu S. Dysregulation of immune response in PCOS organ system[J]. Front Immunol, 2023,14:1169232. doi: 10.3389/fimmu.2023.1169232.
[26]	Mikulska J, Juszczyk G, Gawrońska-Grzywacz M, et al. HPA Axis in the Pathomechanism of Depression and Schizophrenia: New Therapeutic Strategies Based on Its Participation[J]. Brain Sci, 2021, 11(10):1298. doi: 10.3390/brainsci11101298.
[27]	Mamgain A, Sawyer IL, Timajo D, et al. RFamide-Related Peptide Neurons Modulate Reproductive Function and Stress Responses[J]. J Neurosci, 2021, 41(3):474-488. doi: 10.1523/JNEUROSCI.1062-20.2020.
[28]	吴亚琪, 种超杰, 宋家乐, 等. 脑-肠轴参与PCOS发病的主要影响因素及中医药干预的研究进展[J]. 华夏医学, 2023, 36(4):13-19. doi: 10.19296/j.cnki.1008-2409.2023-04-002.
[29]	李佳荣, 张纪岩. 糖皮质激素对免疫细胞调控的研究进展[J]. 中国免疫学杂志, 2024, 40(1):31-36. doi: 10.3969/j.issn.1000-484X.2024.01.004.
[30]	Sarno E, Moeser AJ, Robison AJ. Neuroimmunology of depression[J]. Adv Pharmacol, 2021, 91:259-292. doi: 10.1016/bs.apha.2021.03.004.
[31]	金霞霞, 周锋, 雷正权, 等. 针刺调控5-羟色胺-谷氨酸/γ-氨基丁酸长神经环路防治广泛性焦虑障碍的作用机制探讨[J]. 安徽医药, 2024, 28(3):441-446. doi: 10.3969/j.issn.1009-6469.2024.03.004.
[32]	Hu M, Richard JE, Maliqueo M, et al. Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring[J]. Proc Natl Acad Sci U S A, 2015, 112(46):14348-14353. doi: 10.1073/pnas.1507514112.
[33]	Chaudhari N, Dawalbhakta M, Nampoothiri L. GnRH dysregulation in polycystic ovarian syndrome (PCOS) is a manifestation of an altered neurotransmitter profile[J]. Reprod Biol Endocrinol, 2018, 16(1):37. doi: 10.1186/s12958-018-0354-x.
[34]	Gonzalez D, Maidana P, Ibar C, et al. Hair cortisol in polycystic ovary syndrome[J]. Sci Rep, 2022, 12(1):10309. doi: 10.1038/s41598-022-14061-9. pmid: 35725989
[35]	殷淑君, 康志媛. 多囊卵巢综合征伴高雄激素血症中西医机制研究进展[J]. 辽宁中医药大学学报, 2023, 25(6):172-177. doi: 10.13194/j.issn.1673-842x.2023.06.036.
[36]	Chojnowska S, Ptaszyńska-Sarosiek I, Kpka A, et al. Salivary Biomarkers of Stress, Anxiety and Depression[J]. J Clin Med, 2021, 10(3):517. doi: 10.3390/jcm10030517.
[37]	Semple RK. Insulin Resistance and Adrenal Androgen Synthesis Viewed Through a Monogenic Lens[J]. J Clin Endocrinol Metab, 2022, 107(11):e4326-e4327. doi: 10.1210/clinem/dgac475.
[38]	Livadas S, Chaskou S, Kandaraki AA, et al. Anxiety is associated with hormonal and metabolic profile in women with polycystic ovarian syndrome[J]. Clin Endocrinol(Oxf), 2011, 75(5):698-703. doi: 10.1111/j.1365-2265.2011.04122.x.
[39]	Reagan LP, Cowan HB, Woodruff JL, et al. Hippocampal-specific insulin resistance elicits behavioral despair and hippocampal dendritic atrophy[J]. Neurobiol Stress, 2021,15:100354. doi: 10.1016/j.ynstr.2021.100354.
[40]	赵婧怡, 黄懿, 刘莉洁. 长期高脂饮食对糖脂代谢和焦虑样行为的影响[J]. 营养学报, 2023, 45(6):553-558. doi: 10.3969/j.issn.0512-7955.2023.06.006.
[41]	Song J. Amygdala activity and amygdala-hippocampus connectivity: Metabolic diseases, dementia, and neuropsychiatric issues[J]. Biomed Pharmacother, 2023,162:114647. doi: 10.1016/j.biopha.2023.114647.
[42]	Siddiqui S, Mateen S, Ahmad R, et al. A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS)[J]. J Assist Reprod Genet, 2022, 39(11):2439-2473. doi: 10.1007/s10815-022-02625-7.
[43]	杨新鸣, 胡敏, 彭艳, 等. 基于孕期高雄激素大鼠焦虑行为探讨多囊卵巢综合征与情志的关系[J]. 中国中医急症, 2016, 25(11):2021-2025. doi: 10.3969/j.issn.1004-745X.2016.11.001.
[44]	Palm C, Glintborg D, Find LG, et al. Prenatal Androgen Exposure and Traits of Autism Spectrum Disorder in the Offspring: Odense Child Cohort[J]. J Autism Dev Disord, 2023, 53(3):1053-1065. doi: 10.1007/s10803-022-05446-w.
[45]	Dybciak P, Humeniuk E, Raczkiewicz D, et al. Anxiety and Depression in Women with Polycystic Ovary Syndrome[J]. Medicina(Kaunas), 2022, 58(7):942. doi: 10.3390/medicina58070942.
[46]	徐嗣亮, 马翔, 刘嘉茵, 等. 多囊卵巢综合征患者心理状态评估和心理治疗[J]. 国际生殖健康/计划生育杂志, 2023, 42(6):481-486. doi: 10.12280/gjszjk.20230325.