Abstract: Objective：To evaluate the rate of side effects of GCu200 intrauterine device (IUD) in different periods of insertion, as the safety reference of contraception. Methods：Nine electronic databases including PubMed, EMBASE and CENTRAL, as well as related websites including WHO, FDA and ClinicalTrials, were searched. All literatures were screened according to the inclusion and exclusion criteria by two reviewers. Meta-analysis was conducted using Open Meta-Analyst software. Results：6 864 Chinese literatures were preliminarily retrieved, 10 RCT or quasi-RCT studies were recruited finally. Meta-analysis demonstrated that the rates bleeding and pain were gradually decreased as time went on, and that the infection rate was insignificantly changed within 12 months. At 24 months, the total rate of those side effects was actually very low. The bleeding rate of GCu200 in lactation period insertion was significantly lower than that in intermenstrual period or post-abortion period insertion (P＜0.05), while there were no significant differences in the rates of pain and infection (both P＞0.05). Conclusions：Bleeding was the main side effect in the use of GCu200. Since the insertion during lactation period had lower bleeding rate, this insertion period should be recommended if possible. The follow-up should be strengthened, and the early bleeding after the insertion of GCu200 should be prevented and treated especially, so as to reduce the removal due to side effects.

Key words: Intrauterine devices, copper, Side effects, Follow-up studies, Meta-analysis