Roles of LncRNA in Follicular and Early Embryonic Development

Abstract

Abstract: Long non-coding RNAs (long ncRNAs, lncRNA) are defined as a group of RNAs being longer than 200 nucleotides and lacking the protein-coding ability. LncRNA plays an important role in follicular development and early embryonic development that are closely related to female reproductive health. It has been found that lncRNAs may be involved in follicular development by affecting the proliferation and survival of female germline stem cells and regulating cumulus expansion and oocyte maturation. LncRNA also plays an important role in ovulation, corpus luteum formation and early embryonic development by affecting the proliferation, differentiation and apoptosis of granulosa cells. The study of lncRNA will help us to further understand the molecular mechanism of follicle and early embryonic development, and provide us new diagnostic criteria for evaluating female ovarian reserve and pre-implantation embryo quality and new ideas for the treatment of infertility. This article will review the recent studies on lncRNAs related to the follicular and early embryonic development.

Key words: RNA, Ovarian follicle, Embryonic development, Granulosa cells, Luteinization

KONG Yue，YAO Gui-dong，SUN Ying-pu. Roles of LncRNA in Follicular and Early Embryonic Development[J]. Journal of International Reproductive Health/Family Planning, 2018, 37(6): 504-507.

References

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