Abstract: Objective：To investigate the clinical effect of Buzhong Yiqi granules combined with polysaccharide-iron complex on the iron deficiency anemia (IDA) during pregnancy. Methods：120 pregnant women with IDA were divided into two groups according to the digital random table method, with 60 cases in each group. The control group was treated with polysaccharide-iron complex. The BY-treatment group was treated with Buzhong Yiqi granule (BY) combined with polysaccharide-iron complex. The red blood cell (RBC) count, hemoglobin (Hb), mean hemoglobin (MCH), serum iron (SI), serum ferritin (SF), hepcdin and transferrin receptor (sTfR) were compared between the two groups, before and after treatment. The total effective rate, the incidence of adverse reactions and the outcome of pregnancy were also compared. Results：RBC, Hb, MCH, SI, SF of the BY-treatment group were higher than those of the control group, while hepcdin and sTfR were lower than those of the control group, and the total effective rate was higher than that of the control group (all P＜0.05). There was no significant difference in the incidence of adverse reactions and the outcomes of adverse pregnancy between the two groups (P＞0.05). Conclusions：Buzhong Yiqi granule combined with polysaccharide iron complex can effectively improve iron metabolism, and it is effective and safe in the treatment of IDA during pregnancy.

Key words: Anemia, iron-deficiency, Pregnant women, Polysaccharides, Capsules, Invigorating spleen reinf qi