Abstract: The clinical data of 1 case of giant endometrial polyp (4 cm×2 cm×1 cm) shedding spontaneously in luteal stage were retrospectively analyzed, and the relevant literatures of endometrial polyp were reviewed. The incidence of endometrial polyps is high, however the endometrial polyps larger than 4 cm are rare in clinic. Most patients have no clinical symptoms. Those endometrial polyps smaller than 1 cm are mostly functional polyps, which may be stripped by themselves during menstruation. The etiology and pathogenesis of endometrial polyps are unclear, which is related to the imbalance of estrogen receptor and progesterone receptor, infection and inflammation, oxidative stress, abnormal expression of cytokines, and the imbalance of cell proliferation and apoptosis. Hysteroscopy and hysteroscopic polypectomy are the most simple and effective methods to treat endometrial polyps. Clinically, endometrial polyps smaller than 0.7 cm can be observed. Drug therapy (estrogen-progesterone or progesterone) and LNG-IUS are mostly used to prevent the recurrence of endometrial polyps after hysteroscopic surgery.

Key words: Polyps；, Endometrial neoplasms；, Huge；Case reports