Abstract: MicroRNAs (miRNAs), a kind of endogenous non-coding RNA, can affect the expression of protein by regulating the target gene at the post transcriptional level. MiRNAs involve in the regulation of biological activities of cells in all respects. The low expression, high expression or mutation of specific miRNAs can cause cell dysfunction. Ovarian granulosa cells, the most important somatic cells in follicles which surrounding the oocytes, can synthesize various hormones, growth factors and express their receptors. Those hormones and factors regulate the growth, differentiation and maturation of follicular theca cells and oocytes through gap junction, and then regulate the development of follicles. In addition to the direct effect of miRNAs on oocytes, the regulatory role of miRNAs in granulosa cells is particularly important. It has been found that miRNAs play important roles in the proliferation, differentiation and apoptosis of ovarian granulosa cells, as well as the secretion of sex hormones. In this paper, we reviewed the research progress of miRNAs in ovarian granulosa cells in recent years.

Key words: MicroRNAs；, Granulosa cells；, Oocytes；, Cell proliferation；, Apoptosis