Abstract: Circular RNA (circRNA) is a large class of non-coding RNAs in eukaryotes which is bonded by the reverse splicing. Through binding with corresponding microRNAs or directly contacting with proteins, circRNA exerts the biological functions of cell signal transduction, gene regulation and protein translation, and plays a primarily important role in various physiological and pathological processes. Study found that the abnormality of circRNA could be related to the occurrence and development of female genital tract tumors and female endocrine-related diseases. The potential mechanism of circRNA in female reproductive system and diseases has also been gradually investigated. Owing to the biological characteristics of conservative, stability and tissue specificity, circRNA may be a class of potential diagnostic biomarkers and therapeutic targets of female reproductive system diseases.

Key words: RNA；, MicroRNAs；, Urogenital neoplasms；, Genital diseases, female；, Polycystic ovary syndrome；, Pre-eclampsia