Abstract: Endometrial receptivity, the acceptability of endometrium to embryo, is one of the key factors of successful embryo transfer. The poor endometrial receptivity is a big problem that leads to the low success rate of embryo transfer in those patients with repeated implantation failure. Recently, many experts and scholars have explored various methods to improve endometrial receptivity. A number of studies have shown that mechanical stimulation can improve endometrial receptivity in patients with repeated implantation failure and thus increase the pregnancy rate. Mechanical stimulation of endometrium is a method to induce a series of changes of endometrium in the process of self-healing by artificial injury using curette, biopsy tube or hysteroscopy before embryo transfer, by which improve the endometrial receptivity. Many scholars have studied the mechanism of improving endometrial receptivity by mechanical stimulation from different perspectives, but they have not reached a consistent understanding. In this paper, we discussed the possible mechanism of endometrial mechanical stimulation and research progress, including the changes of ion channels, gene expression, angiogenesis, inflammation and the repair of stem cells.

Key words: Mechanical stimulation；, Endometrium；, Embryo transfer；, Treatment failure；, Infertility, female；, Pregnancy outcome