FMR1 Gene Mutations and Female Fertility and Pregnancy Outcome

doi:10.12280/gjszjk.20200251

Abstract

Abstract:

In recent years, there are more and more diseases of low fertility and repeated fertility failure, such as primary ovarian insufficiency (POI), unexplained early spontaneous abortion, recurrent abortion, embryo termination and so on. Fragile X mental retardation 1 (FMR1) gene is involved in the gene regulation of embryonic development. The mutations of FMR1 gene can cause a variety of female reproductive health diseases. The mutations of FMR1 gene are also related to menopausal age. Therefore, the screening of FMR1 gene has important clinical value in the diagnosis and treatment of female reproductive diseases, and also provides new ideas for the early prevention, diagnosis and treatment of the disease.

Key words: Primary ovarian insufficiency, Repetitive sequences, nucleic acid, Mutation, Fragile X mental retardation protein, Abortion, spontaneous, Menopause, premature, Fragile X mental retardation 1 gene

WANG Mei-yun, ZHOU Jian-zheng. FMR1 Gene Mutations and Female Fertility and Pregnancy Outcome[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(1): 64-68.

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