Research Progress of Sirolimus in the Field of Reproduction

doi:10.12280/gjszjk.20230438

Abstract

Abstract:

Nowadays, sirolimus as a popular immunosuppressant has been frequently used to shield the organ transplant recipients from immunological rejection. The immunomodulatory effects of sirolimus in the female reproductive process have been demonstrated by ongoing medical study. By blocking the immune-regulating action of mammalian target of rapamycin, sirolimus may help those patients with recurrent implantation failure, recurrent spontaneous abortion, endometriosis, chronic endometritis, polycystic ovary syndrome, and other illnesses of the reproductive system. Additionally, sirolimus can enhance the rates of embryo implantation and clinical pregnancy in individuals with aberrant immunological statuses at the mother-fetal interface, reduce ovarian hyperstimulation syndrome during assisted reproductive treatment, and improve the pregnancy outcomes. A review was conducted on the mode of action, research status and safety of sirolimus in female reproductive disorders.

Key words: Sirolimus, Reproductive techniques, assisted, Infertility, female, Abortion, habitual, Endometriosis, Polycystic ovary syndrome, Ovarian hyperstimulation syndrome

YE Lin, HOU Zhi-jin, MENG Yu-shi. Research Progress of Sirolimus in the Field of Reproduction[J]. Journal of International Reproductive Health/Family Planning, 2024, 43(2): 132-137.

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