Research Progress of Epigenetics in Recurrent Spontaneous Abortion

doi:10.12280/gjszjk.20200493

Abstract

Abstract:

Recurrent spontaneous abortion (RSA) is a kind of common pathological pregnancy. The pathogenesis of RSA is complex, involving in many factors such as heredity, endocrine, immune system, abnormal reproductive structure, environment, and so on. Although the incidence of RSA is about 2%-5%, the etiology and pathogenesis of about 50% cases remain unclear. A growing number of studies have shown that epigenetics plays a subtle role in the occurrence and development of RSA through activating or inhibiting the expression of key genes that determine cell differentiation, proliferation and apoptosis. These genes are expected to become potential biomarkers for the diagnosis of RSA, but also new targets for the treatment of RSA. From the perspective of epigenetics, we review the research progress of DNA methylation, histone modification and noncoding RNA regulation in RSA, so as to provide a new perspective for the diagnosis and treatment of RSA.

Key words: Abortion, habitual, Epigenesis, genetic, DNA methylation, Histone modification, RNA, non-coding

ZHU Jing-xi, LI Hong. Research Progress of Epigenetics in Recurrent Spontaneous Abortion[J]. Journal of International Reproductive Health/Family Planning, 2021, 40(1): 69-73.

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